Publication Name	World Journal of Neurology
Manuscript ID	14356
Country	United States

Received	2014-09-29 12:35
Peer-Review Started	2014-10-02 09:49
To Make the First Decision	2014-12-12 17:29
Return for Revision	2014-12-16 11:16
Revised	2015-01-21 08:49
Second Decision	2015-06-08 11:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-07-23 16:34
Articles in Press	2015-07-23 16:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-22 13:45
Publish the Manuscript Online	2015-09-30 16:28

ISSN	2218-6212 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Molecular pathogenesis of glioblastoma multiforme: Nuances, obstacles, and implications for treatment
Manuscript Source	Invited Manuscript
All Author List	Siddharth K Joshi, Nevena Lucic and Richard Zuniga
Funding Agency and Grant Number
Corresponding Author	Richard Zuniga, MD, Division of Hematology/Oncology, Department of Medicine, New York Methodist Hospital, 506 6th Street, Brooklyn, NY 11215, United States. rickzunigaperu@hotmail.com
Key Words	Molecular pathogenesis; Temozolomide; Glioblastoma multiforme; Treatment resistance; Hypoxia; Recurrent glioblastoma multiforme; Bevacizumab
Core Tip	This paper provides the reader with an overview some of the primary molecular markers that are implicated in the pathogenesis glioblastoma multiforme (GBM). It provides a robust review of the evidence that supports the use of these molecular markers for both prognostication and prediction for response to treatment. It gives the reader context for understanding the hypoxia model and how it informs treatment resistance in GBM. It provides an overview of cancer stem cells and their role in GBM biology. And it acquaints the reader with a few of the new, promising treatment modalities that are emerging.
Publish Date	2015-09-30 16:28
Citation	Joshi SK, Lucic N, Zuniga R. Molecular pathogenesis of glioblastoma multiforme: Nuances, obstacles, and implications for treatment. World J Neurol 2015; 5(3): 88-101
URL	http://www.wjgnet.com/2218-6212/full/v5/i3/88.htm
DOI	http://dx.doi.org/10.5316/wjn.v5.i3.88

Full Article (PDF)	WJN-5-88.pdf
Full Article (Word)	WJN-5-88.doc
Manuscript File	14356-Review.doc
Answering Reviewers	14356-Answering reviewers.pdf
Audio Core Tip	14356-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	14356-Conflict-of-interest statement.pdf
Copyright License Agreement	14356-Copyright assignment.pdf
Peer-review Report	14356-Peer-review(s).pdf
Scientific Misconduct Check	14356-Scientific misconduct check.pdf
Scientific Editor Work List	14356-Scientific editor work list .pdf