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9/30/2015 4:28:00 PM | Browse: 1162 | Download: 1402
Publication Name World Journal of Neurology
Manuscript ID 14356
Country/Territory United States
Received
2014-09-29 12:35
Peer-Review Started
2014-10-02 09:49
To Make the First Decision
2014-12-12 17:29
Return for Revision
2014-12-16 11:16
Revised
2015-01-21 08:49
Second Decision
2015-06-08 11:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-07-23 16:34
Articles in Press
2015-07-23 16:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-09-22 13:45
Publish the Manuscript Online
2015-09-30 16:28
ISSN 2218-6212 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Molecular pathogenesis of glioblastoma multiforme: Nuances, obstacles, and implications for treatment
Manuscript Source Invited Manuscript
All Author List Siddharth K Joshi, Nevena Lucic and Richard Zuniga
Funding Agency and Grant Number
Corresponding Author Richard Zuniga, MD, Division of Hematology/Oncology, Department of Medicine, New York Methodist Hospital, 506 6th Street, Brooklyn, NY 11215, United States. rickzunigaperu@hotmail.com
Key Words Molecular pathogenesis; Temozolomide; Glioblastoma multiforme; Treatment resistance; Hypoxia; Recurrent glioblastoma multiforme; Bevacizumab
Core Tip This paper provides the reader with an overview some of the primary molecular markers that are implicated in the pathogenesis glioblastoma multiforme (GBM). It provides a robust review of the evidence that supports the use of these molecular markers for both prognostication and prediction for response to treatment. It gives the reader context for understanding the hypoxia model and how it informs treatment resistance in GBM. It provides an overview of cancer stem cells and their role in GBM biology. And it acquaints the reader with a few of the new, promising treatment modalities that are emerging.
Publish Date 2015-09-30 16:28
Citation Joshi SK, Lucic N, Zuniga R. Molecular pathogenesis of glioblastoma multiforme: Nuances, obstacles, and implications for treatment. World J Neurol 2015; 5(3): 88-101
URL http://www.wjgnet.com/2218-6212/full/v5/i3/88.htm
DOI http://dx.doi.org/10.5316/wjn.v5.i3.88
Full Article (PDF) WJN-5-88.pdf
Full Article (Word) WJN-5-88.doc
Manuscript File 14356-Review.doc
Answering Reviewers 14356-Answering reviewers.pdf
Audio Core Tip 14356-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 14356-Conflict-of-interest statement.pdf
Copyright License Agreement 14356-Copyright assignment.pdf
Peer-review Report 14356-Peer-review(s).pdf
Scientific Misconduct Check 14356-Scientific misconduct check.pdf
Scientific Editor Work List 14356-Scientific editor work list .pdf