Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	14374
Country	United States

Received	2014-09-30 08:18
Peer-Review Started	2014-10-11 08:17
To Make the First Decision	2014-11-14 18:44
Return for Revision	2014-11-19 17:31
Revised	2014-12-06 00:41
Second Decision	2015-02-04 11:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-11 16:07
Articles in Press	2015-02-11 16:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-13 13:48
Publish the Manuscript Online	2015-05-18 10:33

ISSN	1948-5190 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Use of Clostridium botulinum toxin in gastrointestinal motility disorders in children
Manuscript Source	Invited Manuscript
All Author List	Ricardo A Arbizu and Leonel Rodriguez
Funding Agency and Grant Number
Corresponding Author	Leonel Rodriguez, MD, MS, Center for Motility and Functional Gastrointestinal Disorders, Division of Gastroenterology, Department of Medicine, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Bos­ton, MA 02115, United States. leonel.rodriguez@childrens.harvard.edu
Key Words	Botulinum toxin; Gastrointestinal motility disorders; Children; Swallowing disorders; Gastroparesis; Defecation disorders
Core Tip	Clostridium botulinum toxin has been used to alleviate symptoms associated to muscle spams due to excessive neural activity of central origin or to weaken a muscle for treatment purposes. In therapeutic applications, minute quantities of botulinum neurotoxin type A are injected directly into selected muscles. Ever since, therapeutic applications of botulinum toxin have expanded to other systems, including the gastrointestinal tract. This editorial presents the current evidence and evaluates the clinical experience for the use of botulinum toxin in gastrointestinal motility disorders in children.
Publish Date	2015-05-18 10:33
Citation	Arbizu RA, Rodriguez L. Use of Clostridium botulinum toxin in gastrointestinal motility disorders in children. World J Gastrointest Endosc 2015; 7(5): 433-437
URL	http://www.wjgnet.com/1948-5190/full/v7/i5/433.htm
DOI	http://dx.doi.org/10.4253/wjge.v7.i5.433

Full Article (PDF)	WJGE-7-433.pdf
Full Article (Word)	WJGE-7-433.doc
Manuscript File	14374-Review.doc
Answering Reviewers	14374-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14374-Conflict-of-interest statement.pdf
Copyright License Agreement	14374-Copyright assignment.pdf
Peer-review Report	14374-Peer-review(s).pdf
Scientific Misconduct Check	14374-Scientific misconduct check.pdf
Scientific Editor Work List	14374-Scientific editor work list.pdf