Publication Name	World Journal of Neurology
Manuscript ID	14378
Country	Canada

Received	2014-09-30 08:07
Peer-Review Started	2014-10-01 10:44
To Make the First Decision	2014-10-28 14:34
Return for Revision	2014-10-30 18:55
Revised	2014-11-21 02:34
Second Decision	2014-11-28 15:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-12-10 17:44
Articles in Press	2014-12-10 17:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-22 10:54
Publish the Manuscript Online	2014-12-25 18:10

ISSN	2218-6212 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Neurosciences
Manuscript Type	Review
Article Title	Protein seeding in Alzheimer’s disease and Parkinson’s disease: Similarities and differences
Manuscript Source	Invited Manuscript
All Author List	Tarek Ibrahim and JoAnne McLaurin
Funding Agency and Grant Number	Funding Agency Grant Number CIHR MOP 102467 (to McLaurin J)
Corresponding Author	JoAnne McLaurin, PhD, Sunnybrook Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, 2075 Bayview Avenue, Rm S113, Toronto M4N 3M5, Canada. jmclaurin@sri.utoronto.ca
Key Words	Alzheimer’s disease; Parkinson’s disease; Prionoid; Seeding; Propagation; Protein misfolding
Core Tip	The disease-specific proteins of Alzheimer’s and Parkinson’s disease show many similarities as prion-like seeds in the brain. In addition to sharing structural features as misfolded proteins, the interactions and mechanisms that underlie the propagation of these proteins may also be shared, hijacking natural cellular responses in ways not unlike those of pore-forming toxins. Differences in temporal and spatial patterns of disease progression stems from the existence of conformational variants. Misfolded proteins that can be generated in vitro, can seed widespread pathology in non-transgenic animal models and question our understanding of disease progression in neurodegenerative diseases.
Publish Date	2014-12-25 18:10
Citation	Ibrahim T, McLaurin J. Protein seeding in Alzheimer’s disease and Parkinson’s disease: Similarities and differences. World J Neurol 2014; 4(4): 23-35
URL	http://www.wjgnet.com/2218-6212/full/v4/i4/23.htm
DOI	http://dx.doi.org/10.5316/wjn.v4.i4.23

Full Article (PDF)	WJN-4-23.pdf
Full Article (Word)	WJN-4-23.doc
Manuscript File	14378-Review.docx
Answering Reviewers	14378-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14378-Conflict-of-interest statement.pdf
Copyright License Agreement	14378-Copyright assignment.pdf
Peer-review Report	14378-Peer review(s).pdf
Scientific Misconduct Check	14378-CrossCheck.jpg
Scientific Editor Work List	14378-Scientific editor work list.pdf