Publication Name	World Journal of Pharmacology
Manuscript ID	14392
Country	Italy

Received	2014-10-01 11:08
Peer-Review Started	2014-10-01 13:36
To Make the First Decision	2014-10-28 14:33
Return for Revision	2014-10-30 19:54
Revised	2014-11-26 04:42
Second Decision	2015-02-04 11:51
Accepted by Journal Editor-in-Chief	2015-02-05 18:14
Accepted by Executive Editor-in-Chief	2015-02-11 16:09
Articles in Press	2015-02-11 16:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-03 15:31
Publish the Manuscript Online	2015-03-12 19:39

ISSN	2220-3192 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Review
Article Title	Improving cancer therapy by targeting cancer stem cells: Directions, challenges, and clinical results
Manuscript Source	Invited Manuscript
All Author List	Pier Adelchi Ruffini, Valentina Vaja and Marcello Allegretti
Funding Agency and Grant Number
Corresponding Author	Pier Adelchi Ruffini, MD, PhD, Research and Development Department, Dompé Farmaceutici S.p.A., via S. Lucia 6, 20122 Milano, Italy. pieradelchi.ruffini@dompe.com
Key Words	Cancer stem cells; Cancer; Time to new metastasis; Tumor heterogeneity; Drug development
Core Tip	Cancer stem cells are a rare cell population with two embedded fundamental properties: self-renewal and differentiation into the heterogeneous lineages of cancer cells that comprise the tumor. While the identification and role of such cells has been clearly established in vitro and in animal models, uncertainty remains as to the role they play in human tumors and their relevance as therapeutic targets. The article summarizes and discusses the latest findings and challenges on cancer stem cell research, the significance of these cells beyond experimental models and suggests avenues for development of cancer stem cell targeting agents.
Publish Date	2015-03-12 19:39
Citation	Ruffini PA, Vaja V, Allegretti M. Improving cancer therapy by targeting cancer stem cells: Directions, challenges, and clinical results. World J Pharmacol 2015; 4(1): 58-74
URL	http://www.wjgnet.com/2220-3192/full/v4/i1/58.htm
DOI	http://dx.doi.org/10.5497/wjp.v4.i1.58

Full Article (PDF)	WJP-4-58.pdf
Full Article (Word)	WJP-4-58.doc
Manuscript File	14392-Review.docx
Answering Reviewers	14392-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14392-Conflict-of-interest statement.pdf
Copyright License Agreement	14392-Copyright assignment.pdf
Peer-review Report	14392-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	14392-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	14392-Scientific misconduct check.pdf
Scientific Editor Work List	14392-Scientific editor work list.pdf