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Articles Published Processes
3/30/2015 5:46:00 PM | Browse: 1311 | Download: 1820
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Received |
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2014-10-03 13:02 |
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Peer-Review Started |
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2014-10-03 21:21 |
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To Make the First Decision |
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2014-10-29 14:55 |
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Return for Revision |
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2014-11-03 14:28 |
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Revised |
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2014-11-23 04:55 |
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Second Decision |
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2015-01-10 12:15 |
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Accepted by Journal Editor-in-Chief |
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2015-01-10 20:44 |
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Accepted by Executive Editor-in-Chief |
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2015-01-16 18:02 |
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Articles in Press |
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2015-01-16 18:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-03-16 12:08 |
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Publish the Manuscript Online |
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2015-03-30 14:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease: Effect of N-acetyl transferase polymorphisms
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Gabriele Stocco, Eva Cuzzoni, Sara De Iudicibus, Diego Favretto, Noelia Malusà, Stefano Martelossi, Elena Pozzi, Paolo Lionetti, Alessandro Ventura and Giuliana Decorti |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Italian Ministry of Health, and Fondazione Benefica Alberto e Kathleen Casali |
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| Corresponding Author |
Giuliana Decorti, MD, Professor, Department of Life Sciences, University of Trieste, via Fleming 22, I-34127 Trieste, Italy. decorti@units.it |
| Key Words |
Thiopurines; Aminosalicylates; Inflammatory bowel diseases; N-acetyl transferase; Pharmacogenomics |
| Core Tip |
During treatment of inflammatory bowel disease with thiopurines and aminosalicylates, inter?ruption of the aminosalicylate results in a significant decrease in thiopurines’ thioguanine nucleotides (TGN) active metabolites. Genetic polymorphisms in genes involved in aminosalicylates biotransformation (NAT1 genotype) affects TGN levels in patients treated with thiopurines and aminosalicylates and could therefore influence the toxicity and efficacy of these drugs. |
| Publish Date |
2015-03-30 14:23 |
| Citation |
Stocco G, Cuzzoni E, De Iudicibus S, Favretto D, Malusà N, Martelossi S, Pozzi E, Lionetti P, Ventura A, Decorti G. Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease: Effect of N-acetyl transferase polymorphisms. World J Gastroenterol 2015; 21(12): 3571-3578 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i12/3571.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i12.3571 |
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