Publication Name	World Journal of Gastroenterology
Manuscript ID	14405
Country	Italy

Received	2014-10-03 13:02
Peer-Review Started	2014-10-03 21:21
To Make the First Decision	2014-10-29 14:55
Return for Revision	2014-11-03 14:28
Revised	2014-11-23 04:55
Second Decision	2015-01-10 12:15
Accepted by Journal Editor-in-Chief	2015-01-10 20:44
Accepted by Company Editor-in-Chief	2015-01-16 18:02
Articles in Press	2015-01-16 18:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-16 12:08
Publish the Manuscript Online	2015-03-30 14:23

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease: Effect of N-acetyl transferase polymorphisms
Manuscript Source	Invited Manuscript
All Author List	Gabriele Stocco, Eva Cuzzoni, Sara De Iudicibus, Diego Favretto, Noelia Malusà, Stefano Martelossi, Elena Pozzi, Paolo Lionetti, Alessandro Ventura and Giuliana Decorti
Funding Agency and Grant Number	Funding Agency Grant Number Italian Ministry of Health, and Fondazione Benefica Alberto e Kathleen Casali
Corresponding Author	Giuliana Decorti, MD, Professor, Department of Life Sciences, University of Trieste, via Fleming 22, I-34127 Trieste, Italy. decorti@units.it
Key Words	Thiopurines; Aminosalicylates; Inflammatory bowel diseases; N-acetyl transferase; Pharmacogenomics
Core Tip	During treatment of inflammatory bowel disease with thiopurines and aminosalicylates, inter?ruption of the aminosalicylate results in a significant decrease in thiopurines’ thioguanine nucleotides (TGN) active metabolites. Genetic polymorphisms in genes involved in aminosalicylates biotransformation (NAT1 genotype) affects TGN levels in patients treated with thiopurines and aminosalicylates and could therefore influence the toxicity and efficacy of these drugs.
Publish Date	2015-03-30 14:23
Citation	Stocco G, Cuzzoni E, De Iudicibus S, Favretto D, Malusà N, Martelossi S, Pozzi E, Lionetti P, Ventura A, Decorti G. Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease: Effect of N-acetyl transferase polymorphisms. World J Gastroenterol 2015; 21(12): 3571-3578
URL	http://www.wjgnet.com/1007-9327/full/v21/i12/3571.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i12.3571

Full Article (PDF)	WJG-21-3571.pdf
Full Article (Word)	WJG-21-3571.doc
Manuscript File	14405-Review.docx
Answering Reviewers	14405-Answering reviewers.pdf
Biostatistics Review Certificate	14405-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	14405-Conflict-of-interest statement.pdf
Copyright License Agreement	14405-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	14405-Institutional review board statement.pdf
Peer-review Report	14405-Peer-review(s).pdf
Scientific Misconduct Check	14405-CrossCheck.jpg
Scientific Editor Work List	14405-Scientific editor work list.pdf