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Articles Published Processes
3/1/2015 11:51:00 AM | Browse: 1003 | Download: 1405
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Received |
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2014-10-03 12:46 |
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Peer-Review Started |
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2014-10-03 21:49 |
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To Make the First Decision |
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2014-10-29 14:55 |
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Return for Revision |
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2014-11-03 14:37 |
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Revised |
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2014-11-14 06:00 |
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Second Decision |
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2015-01-07 09:02 |
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Accepted by Journal Editor-in-Chief |
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2015-01-08 10:23 |
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Accepted by Company Editor-in-Chief |
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2015-01-16 18:02 |
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Articles in Press |
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2015-01-16 18:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-02-08 15:37 |
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Publish the Manuscript Online |
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2015-02-28 17:07 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
New challenges in perioperative management of pancreatic cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Francesco Puleo, Raphaël Maréchal, Pieter Demetter, Maria-Antonietta Bali, Annabelle Calomme, Jean Closset, Jean-Baptiste Bachet, Jacques Deviere and Jean-Luc Van Laethem |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fonds Erasme, ULB, Brussels |
to Francesco Puleo |
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| Corresponding Author |
Jean-Luc Van Laethem, MD, PhD, Department of Gastroenterology and Digestive Oncology, Erasme Hospital, Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium. jl.vanlaethem@erasme.ulb.ac.be |
| Key Words |
Neoadjuvant chemotherapy; Biomarkers; Preoperative strategies; Pancreatic ductal adenocarcinoma; Personalized medicine |
| Core Tip |
Adoption of preoperative treatment strategies in management of pancreatic ductal adenocarcinoma has the potential to increase resection rates and reduce relapse rates by targeting residual tumor cells and micrometastases early. The use of new, more active chemotherapy regimens such as 5-Fluorouracil, folinic acid, irinotecan and oxaliplatin and nab-paclitaxel plus gemcitabine in the neoadjuvant setting may offer an opportunity to downstage patients with borderline resectable or locally advanced disease to true curative intent R0 resection candidates. A more personalized approach in the setting of a neoadju?vant research platform, using tissue biomarkers and advanced imaging techniques to monitor treatment response could help improve our understanding of tumor biology and ultimately identify patients who could benefit from curative surgery. |
| Publish Date |
2015-02-28 17:07 |
| Citation |
Puleo F, Maréchal R, Demetter P, Bali MA, Calomme A, Closset J, Bachet JB, Deviere J, Van Laethem JL. New challenges in perioperative management of pancreatic cancer. World J Gastroenterol 2015; 21(8): 2281-2293 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i8/2281.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i8.2281 |
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