Publication Name	World Journal of Experimental Medicine
Manuscript ID	14444
Country	Venezuela

Received	2014-10-04 14:57
Peer-Review Started	2014-10-05 11:07
To Make the First Decision	2014-11-14 18:42
Return for Revision	2014-11-20 08:54
Revised	2014-12-05 09:09
Second Decision	2015-03-11 13:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-03-20 10:37
Articles in Press	2015-03-20 10:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-22 16:07
Publish the Manuscript Online	2015-05-21 14:15

ISSN	2220-315x (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review
Manuscript Source	Invited Manuscript
All Author List	Miguel Angel Chiurillo
Funding Agency and Grant Number
Corresponding Author	Miguel Angel Chiurillo, MD, PhD, Laboratorio de Genética Molecular “Dr. Yunis-Turbay”, Decanato de Ciencias de la Salud, Universidad Centroccidental Lisandro Alvarado, Barquisimeto 3001, Estado Lara, Venezuela. mchiurillo@ucla.edu.ve
Key Words	Gastric cancer; Wnt; β-catenin; Oncogene; Tumor suppressor; Epigenetics; Helicobacter pylori; Adenomatous polyposis coli
Core Tip	Available data indicate that Wnt signaling substantially impacts gastric tumorigenesis, prognosis, and resistance to therapy. Loss of Wnt signaling inhibitors (such as APC) by promoter hypermethylation, allelic loss or other mechanisms appear to be particularly important in activating Wnt/β-catenin signaling. Gastric cancer is an entity characterized by its heterogeneity in various aspects, and much remains to be learned about the molecular aspects that determine the process of cancer development in this organ. The role that plays the canonical Wnt pathway in gastric carcinogenesis is reviewed.
Publish Date	2015-05-21 14:15
Citation	Chiurillo MA. Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review. World J Exp Med 2015; 5(2): 84-102
URL	http://www.wjgnet.com/2220-315X/full/v5/i2/84.htm
DOI	http://dx.doi.org/10.5493/wjem.v5.i2.84

Full Article (PDF)	WJEM-5-84.pdf
Full Article (Word)	WJEM-5-84.doc
Manuscript File	14444-Review.docx
Answering Reviewers	14444-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14444-Conflict-of-interest statement.pdf
Copyright License Agreement	14444-Copyright assignment.pdf
Peer-review Report	14444-Peer-review(s).pdf
Scientific Misconduct Check	14444-Scientific misconduct check.pdf
Scientific Editor Work List	14444-Scientific editor work list.pdf