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Articles Published Processes
3/30/2015 5:46:00 PM | Browse: 1048 | Download: 1300
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Received |
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2014-10-05 13:21 |
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Peer-Review Started |
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2014-10-06 20:03 |
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To Make the First Decision |
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2014-10-29 14:54 |
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Return for Revision |
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2014-11-03 15:17 |
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Revised |
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2014-11-05 18:54 |
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Second Decision |
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2014-11-21 09:52 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-12-01 13:55 |
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Articles in Press |
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2014-12-01 14:06 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-12-13 05:46 |
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Typeset the Manuscript |
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2015-03-18 19:36 |
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Publish the Manuscript Online |
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2015-03-30 14:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of entacapone on colon motility and ion transport in a rat model of Parkinson’s disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Sheng Li, Chen-Zhe Liu, Jing-Dong Xu, Li-Fei Zheng, Xiao-Yan Feng, Yue Zhang and Jin-Xia Zhu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81270443 |
| National Natural Science Foundation of China |
81274173 |
| National Natural Science Foundation of China |
31300954 |
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| Corresponding Author |
Jin-Xia Zhu, MD, PhD, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 You An Men Xi Tou Tiao, Beijing 100069, China. zhu_jx@ccmu.edu.cn |
| Key Words |
Parkinson disease; Entacapone; Colon motility; Ion transport; Catechol-O-methyltransferase |
| Core Tip |
Entacapone, a catechol-O-methyltransferase (COMT) inhibitor, is an emerging drug for Parkinson’s disease (PD) patients. However, patients experience gastro-intestinal side effects with entacapone treatment and the reason for this is unknown. This study for the first time proved that COMT is expressed in normal and PD rat colons and that entacapone can inhibit PD rat muscle contraction through the ?2 adrenoceptor. It was also discovered that entacapone can induce cAMP-dependent Cl- secretion in PD rats and that endogenous prostaglandin is involved in this process. These findings provided histological evidence of COMT in the colon, establishing an experimental basis for the mechanism of entacapone-induced PD gastro-intestinal side effects. |
| Publish Date |
2015-03-30 14:23 |
| Citation |
Li LS, Liu CZ, Xu JD, Zheng LF, Feng XY, Zhang Y, Zhu JX. Effect of entacapone on colon motility and ion transport in a rat model of Parkinson’s disease. World J Gastroenterol 2015; 21(12): 3509-3518 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i12/3509.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i12.3509 |
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