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Articles Published Processes
6/29/2015 4:40:00 PM | Browse: 1135 | Download: 1765
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Received |
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2014-10-06 12:48 |
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Peer-Review Started |
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2014-10-06 19:48 |
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To Make the First Decision |
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2014-10-29 15:02 |
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Return for Revision |
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2014-11-03 10:18 |
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Revised |
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2014-11-24 12:46 |
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Second Decision |
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2015-01-28 14:11 |
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Accepted by Journal Editor-in-Chief |
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2015-01-28 14:21 |
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Accepted by Company Editor-in-Chief |
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2015-01-30 15:25 |
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Articles in Press |
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2015-01-30 18:28 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-05-21 18:31 |
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Typeset the Manuscript |
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2015-06-09 17:11 |
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Publish the Manuscript Online |
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2015-06-29 16:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy: A single center report of 8 cases
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Susana Rodrigues, Susana Lopes, Fernando Magro, Hélder Cardoso, Ana Maria Horta e Vale, Margarida Marques, Eva Mariz, Miguel Bernardes, Joanne Lopes, Fátima Carneiro and Guilherme Macedo |
| Funding Agency and Grant Number |
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| Corresponding Author |
Guilherme Macedo, MD, PhD, Department of Gastroenterology, Centro Hospitalar de São João, 4200-319 Porto, Portugal. guilhermemacedo59@gmail.com |
| Key Words |
Anti-tumor necrosis factor antagonist; Autoimmune hepatitis; Adalimumab; Drug-induced liver injury; Inflammatory bowel disease; Infliximab |
| Core Tip |
A total of 8 patients with anti-tumor necrosis factor (TNF)-α-induced autoimmune hepatitis were detected in a single center with over 600 patients. The authors raise the question as to whether most cases represent autoimmune-like drug-induced liver injury (DILI) or defined autoimmune hepatitis (AIH) as the majority of patients responded favorably to steroids and did not require maintenance therapy corresponding to the former. Although anti-TNF therapy-related AIH is rare, a baseline immunological panel along with liver function tests should be performed in all patients with autoimmune disease before starting biologics, in order to detect undiagnosed AIH or help differentiate between DILI and established AIH. |
| Publish Date |
2015-06-29 16:33 |
| Citation |
Rodrigues S, Lopes S, Magro F, Cardoso H, Horta e Vale AM, Marques M, Mariz E, Bernardes M, Lopes J, Carneiro F, Macedo G. Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy: A single center report of 8 cases. World J Gastroenterol 2015; 21(24): 7584-7588 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i24/7584.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i24.7584 |
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