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Articles Published Processes
4/27/2015 4:29:00 PM | Browse: 1000 | Download: 2116
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Received |
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2014-10-11 13:32 |
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Peer-Review Started |
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2014-10-11 14:48 |
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To Make the First Decision |
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2014-10-29 15:02 |
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Return for Revision |
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2014-11-03 10:22 |
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Revised |
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2014-11-24 21:49 |
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Second Decision |
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2014-12-04 14:44 |
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Accepted by Journal Editor-in-Chief |
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2014-12-05 03:30 |
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Accepted by Company Editor-in-Chief |
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2014-12-16 10:06 |
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Articles in Press |
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2014-12-16 10:39 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-01-12 11:27 |
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Typeset the Manuscript |
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2015-04-13 16:10 |
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Publish the Manuscript Online |
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2015-04-27 16:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Inflammatory microenvironment and expression of chemokines in hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ke-Qi Han, Xue-Qun He, Meng-Yu Ma, Xiao-Dong Guo, Xue-Min Zhang, Jie Chen, Hui Han, Wei-Wei Zhang, Quan-Gang Zhu, Hua Nian and Li-Jun Ma |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of China |
81072954 |
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| Corresponding Author |
Dr. Li-Jun Ma, Department of Oncology, Tongren Hospital of Shanghai Jiaotong University School of Medicine, 1111 Xianxia Road, Shanghai 200336, China. ljma5@hotmail.com |
| Key Words |
Chemokines; Gene expression profile; Hepatocellular carcinoma; PCR array; RNA interference |
| Core Tip |
An orthotopic transplantation tumor model of hepatocellular carcinoma (HCC) with CBRH-7919 cells was established. Inflammatory cell infiltration and macrophage phenotype were assessed by immunohistochemistry. A chemokine PCR array was used to identify differentially expressed genes, and tumor growth was assessed after knockdown with RNA interference. This study describes the inflammatory microenvironment and differential expression of chemokines in hepatocellular carcinoma. The data suggest that CXCL1 plays a critical role in tumor growth and may serve as a potential molecular target for use in HCC therapy. |
| Publish Date |
2015-04-27 16:22 |
| Citation |
Han KQ, He XQ, Ma MY, Guo XD, Zhang XM, Chen J, Han H, Zhang WW, Zhu QG, Nian H, Ma LJ. Inflammatory microenvironment and expression of chemokines in hepatocellular carcinoma. World J Gastroenterol 2015; 21(16): 4864-4874 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i16/4864.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i16.4864 |
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