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Articles Published Processes
5/18/2015 5:02:00 PM | Browse: 1010 | Download: 1604
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Received |
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2014-10-09 09:59 |
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Peer-Review Started |
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2014-10-09 14:33 |
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To Make the First Decision |
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2014-11-14 18:58 |
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Return for Revision |
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2014-11-20 09:10 |
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Revised |
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2014-11-28 17:49 |
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Second Decision |
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2014-12-16 15:26 |
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Accepted by Journal Editor-in-Chief |
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2014-12-18 10:19 |
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Accepted by Executive Editor-in-Chief |
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2014-12-22 17:02 |
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Articles in Press |
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2014-12-22 17:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-04-24 14:25 |
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Publish the Manuscript Online |
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2015-05-18 17:02 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung’s disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Anne Marie O’Donnell, David Coyle and Prem Puri |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Children’s Research Centre/Children’s Medical Research Foundation, Ireland |
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| Corresponding Author |
Prem Puri, Professor, MS, FRCS, FRCS (Ed), FACS, FAAP (Hon.), DSc (Hon.), National Children’s Research Centre, Our Lady’s Children’s Hospital, Cooley Rd, Crumlin, Dublin 12, Ireland. prem.puri@ucd.ie |
| Key Words |
Hyperpolarisation-activated nucleotide-gated; Interstitial cells of Cajal; Hirschsprung’s; Pacemaker; Ih current |
| Core Tip |
Children with Hirschsprung’s disease experience symptoms of intestinal obstruction due to a spastically contracted aganglionic segment of distal bowel, however the mechanism for this spasticity is incompletely under?stood. Hyperpolarisation-activated nucleotide-gated channels play a key role in regulating cell excitability in both pacemaker and non-pacing cells. We examined expression of hyperpolarisation-activated nucleotide-gated (HCN) 1-4 in both Hirschsprung’s disease (HSCR) colon and healthy controls. While HCN-1 expression was absent, and HCN-2 and HCN-4 were expressed at similar levels in diseased and healthy bowel, we found HCN-3 to be reduced in aganglionic bowel in HSCR. We suggest deficient HCN3 channels may be involved in the pathophysiology of HSCR. |
| Publish Date |
2015-05-18 17:02 |
| Citation |
O’Donnell AM, Coyle D, Puri P. Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung’s disease. World J Gastroenterol 2015; 21(18): 5635-5640 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i18/5635.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i18.5635 |
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