Publication Name	World Journal of Gastroenterology
Manuscript ID	1452
Country	China

Received	2012-12-12 20:27
Peer-Review Started	2012-12-13 14:52
To Make the First Decision	2013-01-24 18:47
Return for Revision	2013-01-25 14:17
Revised	2013-02-18 20:36
Second Decision	2013-04-18 16:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-04-19 06:24
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-17 20:39
Publish the Manuscript Online	2013-05-28 09:36

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Value of circulating cell-free DNA in diagnosis of hepatocelluar carcinoma
Manuscript Source	Invited Manuscript
All Author List	Ken Chen, Hong Zhang, Li-Na Zhang, Shao-Qing Ju, Jing Qi, Dong-Feng Huang, Feng Li, Qun Wei and Jing Zhang
Funding Agency and Grant Number
Corresponding Author	Hong Zhang, MD, Department of Gastroenterology, Affiliated Hospital of Nantong University, 20 Xisi Street, Nantong 226000, Jiangsu Province, China. zhangh111@sina.com
Key Words	Alu; Branched DNA; Circulating cell free DNA; Diagnosis; Hepatocellular carcinoma
Core Tip	Various techniques are available to quantify serum circulating free cell DNA (cfDNA), some of these techniques require abstraction and purification as there is only a very small amount of cfDNA in the serum. This study investigates the value of combined detection of cfDNA, ?-fetal protein (AFP) and ? L-fucosidase (AFU) for diagnosis of hepatocellular carcinoma. Quantitative analysis of cfDNA is sensitive and feasible, and the combined detection of cfDNA with AFP or AFU or both could improve the diagnostic sensitivity for hepatocellular carcinoma.
Publish Date	2013-05-28 09:36
Citation	Chen K, Zhang H, Zhang LN, Ju SQ, Qi J, Huang DF, Li F, Wei Q, Zhang J. Value of circulating cell-free DNA in diagnosis of hepatocelluar carcinoma. World J Gastroenterol 2013; 19(20): 3143-3149
URL	http://www.wjgnet.com/1007-9327/full/v19/i20/3143.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i20.3143

Full Article (PDF)	WJG-19-3143.pdf
Manuscript File	1452-Review.doc
Answering Reviewers	1452-Answering reviewers.pdf
Copyright License Agreement	1452-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	1452-Language cetificate.doc
Peer-review Report	1452-Peer review.pdf
Scientific Editor Work List	1452-Scientific editor work list.doc