Publication Name	World Journal of Gastroenterology
Manuscript ID	14537
Country	France

Received	2014-10-10 17:43
Peer-Review Started	2014-10-11 08:26
To Make the First Decision	2014-11-14 18:54
Return for Revision	2014-11-20 09:13
Revised	2014-11-25 08:23
Second Decision	2014-12-04 14:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-12-16 10:07
Articles in Press	2014-12-16 10:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-22 17:36
Publish the Manuscript Online	2015-02-09 17:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Minireviews
Article Title	Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities
Manuscript Source	Invited Manuscript
All Author List	Jean-Noël Freund, Isabelle Duluc, Jean-Marie Reimund, Isabelle Gross and Claire Domon-Dell
Funding Agency and Grant Number
Corresponding Author	Jean-Noël Freund, PhD, INSERM UMR_S1113, Université de Strasbourg, FMTS, 3 Avenue Molière, 67200 Strasbourg, France. jean-noel.freund@inserm.fr
Key Words	Homeobox; Transcription; Signaling; DNA repair; RNA splicing; Intestine; Development; Cancer; Homeostasis
Core Tip	The homeobox gene Cdx2 plays crucial functions in the gut, being the one determinant of intestinal identity during embryonic development, and then a key regulator of homeostasis of the gut epithelium throughout adulthood. It acts at the level of the stem/progenitor cells as well as in mature epithelial cells. Cdx2 is also important in digestive diseases, especially in colorectal cancer where it is thought to have a tumor suppressor role. In addition, it becomes abnormally expressed ectopically in non-intestinal organs, including gastric intestinal-type metaplasia and Barrett’s esophagus and their related adenocarcinomas, and even in leukemia. The homeoprotein Cdx2 primarily acts as a DNA-binding transcription factor. However, recent reports provide evidence for novel mechanisms of action that are transcription-independent. In this review, we summarize these new data that considerably extend the molecular potential of Cdx2 and open new questions and research area regarding the role of this homeoprotein in physiology and pathology.
Publish Date	2015-02-09 17:58
Citation	Freund JN, Duluc I, Reimund JM, Gross I, Domon-Dell C. Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities. World J Gastroenterol 2015; 21(5): 1436-1443
URL	http://www.wjgnet.com/1007-9327/full/v21/i5/1436.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i5.1436

Full Article (PDF)	WJG-21-1436.pdf
Full Article (Word)	WJG-21-1436.doc
Manuscript File	14537-Review.doc
Answering Reviewers	14537-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14537-Conflict of interest.pdf
Copyright License Agreement	14537-Copyright assignment.pdf
Peer-review Report	14537-Peer review(s）.pdf
Scientific Misconduct Check	14537-CorssCheck.jpg
Scientific Editor Work List	14537-Scientific editor work list.pdf