Publication Name	World Journal of Gastroenterology
Manuscript ID	14538
Country	China

Received	2014-10-10 17:36
Peer-Review Started	2014-10-10 17:36
To Make the First Decision	2014-11-14 19:08
Return for Revision	2014-12-25 09:36
Revised
Second Decision	2015-03-25 16:27
Accepted by Journal Editor-in-Chief	2015-03-25 16:52
Accepted by Executive Editor-in-Chief	2015-03-31 10:16
Articles in Press	2015-03-31 11:08
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-05-10 21:55
Typeset the Manuscript	2015-05-13 19:26
Publish the Manuscript Online	2015-05-30 13:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Expression of COX-2 and HER-2 in colorectal cancer and their correlation
Manuscript Source	Unsolicited Manuscript
All Author List	Qi-Bing Wu and Guo-Ping Sun
Funding Agency and Grant Number
Corresponding Author	Guo-Ping Sun, PhD, Professor, Department of Oncology, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Shushan District, Hefei 230022, Anhui Province, China. sunguoping@ahmu.edu.cn
Key Words	Colorectal cancer; Correlation; COX-2; HER-2; Immunohistochemistry; Survival rate
Core Tip	The relationship between and expression of COX-2 and HER-2 in colorectal cancer have not been fully elucidated. In this study, the expression of COX-2 and HER-2 was assessed in colorectal cancer tissues by immunohistochemistry, and the correlations between COX-2 and HER-2 expression and colorectal cancer clinical features were evaluated. Results demonstrated that COX-2 and HER-2 expression are significantly associated with serosal invasion, lymph node metastasis, Duke’s stage, and poorly differentiated cancer. COX-2 and HER-2 have synergistic effects in colorectal cancer. Both COX-2 and HER-2 are important markers for invasion and metastasis of colorectal cancer.
Publish Date	2015-05-30 13:32
Citation	Wu QB, Sun GP. Expression of COX-2 and HER-2 in colorectal cancer and their correlation. World J Gastroenterol 2015; 21(20): 6206-6214
URL	http://www.wjgnet.com/1007-9327/full/v21/i20/6206.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i20.6206

Full Article (PDF)	WJG-21-6206.pdf
Full Article (Word)	WJG-21-6206.doc
Manuscript File	14538-Review.doc
Answering Reviewers	14538-Answering reviewers.pdf
Copyright License Agreement	14538-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	14538-Institutional review board statement.pdf
Peer-review Report	14538-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	14538-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	14538-Scientific misconduct check.pdf
Scientific Editor Work List	14538-Scientific editor work list.pdf