Publication Name	World Journal of Cardiology
Manuscript ID	14578
Country	United Kingdom

Received	2014-10-13 18:01
Peer-Review Started	2014-10-14 09:31
To Make the First Decision	2015-01-08 14:10
Return for Revision	2015-01-13 15:15
Revised	2015-02-25 22:59
Second Decision	2015-03-09 09:25
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-03-18 16:57
Articles in Press	2015-03-18 16:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-04 13:50
Publish the Manuscript Online	2015-05-21 13:54

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Mitochondrial function and regulation of macrophage sterol metabolism and inflammatory responses
Manuscript Source	Invited Manuscript
All Author List	Annette Graham and Anne-Marie Allen
Funding Agency and Grant Number
Corresponding Author	Annette Graham, PhD, Department of Life Sciences, School of Health and Life Sciences and the Institute for Applied Health Research (Diabetes Research Group), Glasgow Caledonian University, Cowcaddens Road, G4 0BA Glasgow, United Kingdom. ann.graham@gcu.ac.uk
Key Words	Atherosclerosis; Macrophage; Cholesterol; High density lipoproteins; Apolipoproteins; ATP binding cassette transporters; Scavenger receptor B1; Mitochondria (dys)function; Sterol 27-hydroxylase; Liver X receptors
Core Tip	Mitochondrial cholesterol trafficking to CYP27A1 located on the inner mitochondrial membrane regulates the formation of oxysterol ligands for liver X receptors (LXRs) in sterol-laden macrophage “foam” cells. In turn, ligation of LXR? has profound implications for sterol removal and inflammatory responses in macrophage “foam” cells, both factors which may contribute to the effective resolution of atherosclerotic lesions and reductions in the incidence of coronary heart disease and its sequelae.
Publish Date	2015-05-21 13:54
Citation	Graham A, Allen AM. Mitochondrial function and regulation of macrophage sterol metabolism and inflammatory responses. World J Cardiol 2015; 7(5): 277-286
URL	http://www.wjgnet.com/1949-8462/full/v7/i5/277.htm
DOI	http://dx.doi.org/10.4330/wjc.v7.i5.277

Full Article (PDF)	WJC-7-277.pdf
Full Article (Word)	WJC-7-277.doc
Manuscript File	14578-Review.doc
Answering Reviewers	14578-Answering reviewers.pdf
Audio Core Tip	14578-Audio core tip.wav
Conflict-of-Interest Disclosure Form	14578-Conflict-of-interest statement.pdf
Copyright License Agreement	14578-Copyright assignment.pdf
Peer-review Report	14578-Peer-review(s).pdf
Scientific Misconduct Check	14578-Scientific misconduct check.pdf
Scientific Editor Work List	14578-Scientific editor work list.pdf