Publication Name	World Journal of Radiology
Manuscript ID	14592
Country	United States

Received	2014-10-14 16:53
Peer-Review Started	2014-10-15 08:13
To Make the First Decision	2014-12-17 11:23
Return for Revision	2014-12-19 14:15
Revised	2014-12-25 11:05
Second Decision	2015-01-14 09:19
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-01-20 16:42
Articles in Press	2015-01-20 16:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-02-07 20:36
Publish the Manuscript Online	2015-02-12 11:17

ISSN	1949-8470 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Retrospective Study
Article Title	Transcranial Doppler screening in sickle cell disease: The implications of using peak systolic criteria
Manuscript Source	Invited Manuscript
All Author List	Lena N Naffaa, Yasmeen K Tandon and Neville Irani
Funding Agency and Grant Number
Corresponding Author	Lena N Naffaa, MD, Radiologist, Department of Radiology, Akron Children’s Hospital, 1 Perkins Square, Akron, OH 44308, United States. lnaffaa@chmca.org
Key Words	Sickle; Ischemic; Stroke; Trans Cranial Doppler; Average maximum mean velocity; Peak systolic velocity; Magnetic resonance imaging
Core Tip	To the best of our knowledge, there has been no direct comparison between peak systolic velocity and time average maximum mean velocity in their ability to predict abnormalities on magnetic resonance imaging (MRI)/magnetic resonance angiogram in children with sickle cell disease. With the growing clinical use of MR Angiography to assess sickle cell patients, the sensitivity of Trans Cranial Doppler (TCD) should be maximized if it is to maintain its role as a screening test in the sickle cell population. Based on the data obtained at our institution and using the assumption that the best screening test is the one with the highest sensitivity, the peak systolic velocity could be the measurement of choice for TCD screening.
Publish Date	2015-02-12 11:17
Citation	Naffaa LN, Tandon YK, Irani N. Transcranial Doppler screening in sickle cell disease: The implications of using peak systolic criteria. World J Radiol 2015; 7(2): 52-56
URL	http://www.wjgnet.com/1949-8470/full/v7/i2/52.htm
DOI	http://dx.doi.org/10.4329/wjr.v7.i2.52

Full Article (PDF)	WJR-7-52.pdf
Full Article (Word)	WJR-7-52.doc
Manuscript File	14592-Review.doc
Answering Reviewers	14592-Answering reviewers.pdf
Biostatistics Review Certificate	14592-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	14592-Conflict-of-interest statement.pdf
Copyright License Agreement	14592-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	14592-Institutional review board statement.pdf
Peer-review Report	14592-Peer review(s).pdf
Scientific Misconduct Check	14592-CrossCheck.jpg
Scientific Editor Work List	14592-Scientific editor work list.pdf