| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Expression of pyruvate dehydrogenase is an independent prognostic marker in gastric cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xu-Ren Sun, Zhe Sun, Zhi Zhu, Hai-Xia Guan, Chen-Yan Li, Jun-Yan Zhang, Yi-Ning Zhang, Huan Zhou, Hui-Jing Zhang, Hui-Mian Xu and Ming-Jun Sun |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Liaoning Province Science and Technology Department |
2007225017 |
| Liaoning Province Science and Technology Department |
2009225011-2 |
| Liaoning Province Science and Technology Department |
2011415052 |
| Science and Technology projects in Shenyang City |
F11-264-1-19 |
|
| Corresponding Author |
Ming-Jun Sun, MD, Department of Gastroenterology, First Affiliated Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang 110001, Liaoning Province, China. smjmw@sina.com |
| Key Words |
Pyruvate dehydrogenase; Gastric carcinoma; Tissue microarray; Prognosis; Immunohistochemical analysis |
| Core Tip |
This is the first reported study to evaluate the prognostic role of pyruvate dehydrogenase (PDH) expression in gastric cancer (GC). This study showed that reduced PDH expression was correlated with Lauren grade, lymph node metastasis, lymphatic invasion, histologic subtype and TNM stage in GC. We propose that increased PDH expression may contribute to a decrease in the proliferation and development of GC. In particular, PDH protein expression was found to positively correlate with survival in GC patients, and a high level of PDH expression was found to be associated with better overall survival in patients with resected GC. In conclusion, this study showed that PDH expression is an independent prognostic factor in gastric carcinomas. |
| Publish Date |
2015-05-13 10:38 |
| Citation |
Sun XR, Sun Z, Zhu Z, Guan HX, Li CY, Zhang JY, Zhang YN, Zhou H, Zhang HJ, Xu HM, Sun MJ. Expression of pyruvate dehydrogenase is an independent prognostic marker in gastric cancer. World J Gastroenterol 2015; 21(17): 5336-5344 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i17/5336.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i17.5336 |
