Publication Name	World Journal of Gastroenterology
Manuscript ID	14596
Country	China

Received	2014-10-14 16:40
Peer-Review Started	2014-10-15 15:06
First Decision by Editorial Office Director
Return for Revision	2014-12-16 16:08
Revised	2014-12-30 22:06
Publication Fee Transferred
Second Decision by Editor	2015-01-29 12:25
Second Decision by Editor-in-Chief	2015-01-29 15:51
Final Decision by Editorial Office Director	2015-02-12 17:25
Articles in Press	2015-02-13 11:19
Edit the Manuscript by Language Editor	2015-04-13 13:24
Typeset the Manuscript	2015-04-20 14:10
Publish the Manuscript Online	2015-05-13 10:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Expression of pyruvate dehydrogenase is an independent prognostic marker in gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Xu-Ren Sun, Zhe Sun, Zhi Zhu, Hai-Xia Guan, Chen-Yan Li, Jun-Yan Zhang, Yi-Ning Zhang, Huan Zhou, Hui-Jing Zhang, Hui-Mian Xu and Ming-Jun Sun
Funding Agency and Grant Number	Funding Agency Grant Number Liaoning Province Science and Technology Department 2007225017 Liaoning Province Science and Technology Department 2009225011-2 Liaoning Province Science and Technology Department 2011415052 Science and Technology projects in Shenyang City F11-264-1-19
Corresponding Author	Ming-Jun Sun, MD, Department of Gastroenterology, First Affiliated Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang 110001, Liaoning Province, China. smjmw@sina.com
Key Words	Pyruvate dehydrogenase; Gastric carcinoma; Tissue microarray; Prognosis; Immunohistochemical analysis
Core Tip	This is the first reported study to evaluate the prognostic role of pyruvate dehydrogenase (PDH) expression in gastric cancer (GC). This study showed that reduced PDH expression was correlated with Lauren grade, lymph node metastasis, lymphatic invasion, histologic subtype and TNM stage in GC. We propose that increased PDH expression may contribute to a decrease in the proliferation and development of GC. In particular, PDH protein expression was found to positively correlate with survival in GC patients, and a high level of PDH expression was found to be associated with better overall survival in patients with resected GC. In conclusion, this study showed that PDH expression is an independent prognostic factor in gastric carcinomas.
Publish Date	2015-05-13 10:38
Citation	Sun XR, Sun Z, Zhu Z, Guan HX, Li CY, Zhang JY, Zhang YN, Zhou H, Zhang HJ, Xu HM, Sun MJ. Expression of pyruvate dehydrogenase is an independent prognostic marker in gastric cancer. World J Gastroenterol 2015; 21(17): 5336-5344
URL	http://www.wjgnet.com/1007-9327/full/v21/i17/5336.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i17.5336

Full Article (PDF)	WJG-21-5336.pdf
Full Article (Word)	WJG-21-5336.doc
Manuscript File	14596-Review.doc
Answering Reviewers	14596-Answering reviewers.pdf
Biostatistics Review Certificate	14596-Biostatistics statement.pdf
Clinical Trial Registration Statement	14596-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	14596-Conflict-of-interest statement.pdf
Copyright License Agreement	14596-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	14596-Clinical trial registration.pdf
Institutional Review Board Approval Form or Document	14596-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	14596-Language certificate.pdf
Peer-review Report	14596-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	14596-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	14596-Scientific misconduct check.pdf