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Articles Published Processes
6/11/2015 10:11:00 AM | Browse: 980 | Download: 1269
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Received |
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2014-10-15 08:49 |
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Peer-Review Started |
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2014-10-15 14:04 |
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To Make the First Decision |
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2015-01-08 16:59 |
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Return for Revision |
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2015-01-12 17:20 |
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Revised |
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2015-02-07 02:22 |
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Second Decision |
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2015-03-25 16:31 |
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Accepted by Journal Editor-in-Chief |
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2015-03-26 02:40 |
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Accepted by Executive Editor-in-Chief |
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2015-03-31 10:27 |
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Articles in Press |
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2015-03-31 11:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-05-28 10:28 |
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Publish the Manuscript Online |
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2015-06-11 10:11 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
New NCI-N87-derived human gastric epithelial line after human telomerase catalytic subunit over-expression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kathy Saraiva-Pava, Nazanin Navabi, Emma C Skoog, Sara K Lindén, Mónica Oleastro and Mónica Roxo-Rosa |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fundação para a Ciência e a Tecnologia |
PPCDT/SAL-IMI/57297/2004 |
| Fundação para a Ciência e a Tecnologia |
PTDC/BIM-MEC/1051/2012 |
| Swedish Cancer foundation; The Swedish Research Council |
K2010-79X-21372-01-3 |
| Forska utan djurförsök, Animal Free Research |
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| Sociedade Portuguesa de Gastrenterologia |
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| Corresponding Author |
Mónica Oleastro, PhD, Departamento de Doenças Infeciosas, Instituto Nacional Saúde Dr. Ricardo Jorge, Av. Padre Cruz, 1649-016 Lisboa, Portugal. monica.oleastro@insa.min-saude.pt |
| Key Words |
Helicobacter pylori infection; Pathogenesis; Human gastric epithelium; Cellular model; NCI-N87 cells |
| Core Tip |
In this study, we aimed to establish and characterize novel human gastric epithelial cell lines derived from NCI-N87 cells after over-expression of human telomerase catalytic activity. The two most promising NCI-N87-derived clones were shown to be composed of cells with homogenous phenotype, to produce gastric zymogens and to produce and secrete neutral mucins. In addition, these clones showed very good in vitro growth properties, resistance to microaerobic conditions and good responsiveness to Helicobacter pylori. Due to their improved properties, compared to the heterogeneous parental line, these NCI-N87-derived clones are promising models of the human gastric epithelium. |
| Publish Date |
2015-06-11 10:11 |
| Citation |
Saraiva-Pava K, Navabi N, Skoog EC, Lindén SK, Oleastro M, Roxo-Rosa M. New NCI-N87-derived human gastric epithelial line after human telomerase catalytic subunit over-expression. World J Gastroenterol 2015; 21(21): 6526-6542 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i21/6526.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i21.6526 |
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