Publication Name	World Journal of Critical Care Medicine
Manuscript ID	14632
Country	United States

Received	2014-10-16 08:11
Peer-Review Started	2014-10-16 15:57
To Make the First Decision	2014-12-17 11:23
Return for Revision	2014-12-19 14:29
Revised	2015-01-13 22:44
Second Decision	2015-01-28 11:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-09 10:34
Articles in Press	2015-02-09 10:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-07 12:05
Publish the Manuscript Online	2015-04-23 11:46

ISSN	2220-3141(online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Critical Care Medicine
Manuscript Type	Review
Article Title	Anticoagulant modulation of inflammation in severe sepsis
Manuscript Source	Invited Manuscript
All Author List	Karen S Allen, Eva Sawheny and Gary T Kinasewitz
Funding Agency and Grant Number
Corresponding Author	Karen S Allen, MD, Assistant Professor of Medicine, Section of Pulmonary and Critical Care, University of Oklahoma Health Sciences Center, 920 Stanton L Young Blvd WP1310, Oklahoma City, OK 73104, United States. karen-allen@ouhsc.edu
Key Words	Inflammation; Protein C; Heparin; Tissue factor pathway inhibitor; Thrombomodulin; Antithrombin; Sepsis; Coagulation; Neutrophil extracellular traps
Core Tip	The interaction between the coagulation and inflammatory cascade contributes to the overall patho?physiology of severe sepsis. These processes become unchecked and thus can lead to significant morbidity and mortality. Many anticoagulants have been studied in clinical trials as a means to modulate the inflammatory and coagulation cascade with the aim to improve outcomes for septic patients via modulation of these cascades. This article outlines the pathophysiology and interaction between inflammation and coagulation in severe sepsis and also reviews the anticoagulants previously studied for modulation.
Publish Date	2015-04-23 11:46
Citation	Allen KS, Sawheny E, Kinasewitz GT. Anticoagulant modulation of inflammation in severe sepsis. World J Crit Care Med 2015; 4(2): 105-115
URL	http://www.wjgnet.com/2220-3141/full/v4/i2/105.htm
DOI	http://dx.doi.org/10.5492/wjccm.v4.i2.105

Full Article (PDF)	WJCCM-4-105.pdf
Full Article (Word)	WJCCM-4-105.doc
Manuscript File	14632-Review.doc
Answering Reviewers	14632-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14632-Conflict-of-interest statement.pdf
Copyright License Agreement	14632-Copyright assignment.pdf
Supplementary Material	14632-Supplementary Material.doc
Peer-review Report	14632-Peer-review(s).pdf
Scientific Misconduct Check	14632-Scientific misconduct check.pdf
Scientific Editor Work List	14632-Scientific editor work list.pdf