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Articles Published Processes
7/8/2015 12:00:00 PM | Browse: 1138 | Download: 1770
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Received |
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2014-10-17 08:44 |
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Peer-Review Started |
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2014-10-18 15:13 |
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To Make the First Decision |
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2014-12-02 09:24 |
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Return for Revision |
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2014-12-03 17:08 |
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Revised |
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2015-01-03 01:24 |
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Second Decision |
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2015-02-11 22:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-02-12 17:32 |
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Articles in Press |
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2015-02-13 11:19 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-06-08 23:37 |
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Typeset the Manuscript |
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2015-06-25 10:19 |
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Publish the Manuscript Online |
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2015-07-08 12:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Basic Study |
| Article Title |
TLR2 and TLR4 polymorphisms influence mRNA and protein expression in colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Marcela Alcântara Proença, Juliana Garcia de Oliveira, Aline Cristina Targa Cadamuro, Maysa Succi, João Gomes Netinho, Eny Maria Goloni-Bertolo, Érika Cristina Pavarino and Ana Elizabete Silva |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Brazilian agencies FAPESP |
2012/15036-8 |
| CNPq |
304870/2012-9 |
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| Corresponding Author |
Ana Elizabete Silva, PhD, Department of Biology, UNESP, São Paulo State University, Rua Cristóvão Colombo, 2265, São José do Rio Preto 15054-000, SP, Brazil. anabete@ibilce.unesp.br |
| Key Words |
Toll-like receptor 2; Toll-like receptor 4; Colorectal cancer; Protein expression; Gene expression; Genetic polymorphisms |
| Core Tip |
This study investigated the influence of the toll-like receptor (TLR)2 and TLR4 functional polymorphisms on mRNA and protein expression levels in colorectal cancer samples and the association of these polymorphisms with the risk of developing this neoplasm. Increased expression of TLR2 (mRNA and protein) in tumor tissue was observed compared with adjacent normal tissue. Moreover, for the first time, the polymorphism TLR2-196 to -174del was associated with a higher risk of developing this type of cancer, and TLR2-196 to -174del allele carriers showed mRNA relative expression approximately two times higher than wild-genotype carriers. Thus, functional polymorphism in TLR2 may change gene expression levels, accentuating inflammation and aggravating the development of colorectal cancer. |
| Publish Date |
2015-07-08 12:01 |
| Citation |
Proença MA, de Oliveira JG, Cadamuro ACT, Succi M, Netinho JG, Goloni-Bertolo EM, Pavarino ÉC, Silva AE. TLR2 and TLR4 polymorphisms influence mRNA and protein expression in colorectal cancer. World J Gastroenterol 2015; 21(25): 7730-7741 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i25/7730.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i25.7730 |
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