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Articles Published Processes
4/15/2015 11:01:00 AM | Browse: 1503 | Download: 2628
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Received |
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2014-10-18 13:24 |
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Peer-Review Started |
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2014-10-19 12:09 |
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To Make the First Decision |
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2014-12-02 09:23 |
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Return for Revision |
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2014-12-03 18:07 |
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Revised |
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2014-12-17 10:18 |
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Second Decision |
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2015-02-11 22:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-02-12 17:33 |
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Articles in Press |
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2015-02-13 11:19 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-03-07 23:52 |
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Typeset the Manuscript |
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2015-03-27 15:34 |
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Publish the Manuscript Online |
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2015-04-15 11:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Toxicology |
| Manuscript Type |
Basic Study |
| Article Title |
Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing-Yao Zhang, Si-Dong Song, Qing Pang, Rui-Yao Zhang, Yong Wan, Da-Wei Yuan, Qi-Fei Wu and Chang Liu |
| Funding Agency and Grant Number |
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| Corresponding Author |
Chang Liu, MD, PhD, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an 710061, Shaanxi Province, China. liuchangdoctor@163.com |
| Key Words |
Hydrogen; Liver regeneration; Reactive oxygen species; Acetaminophen; Connexin 32 |
| Core Tip |
Acetaminophen (APAP)-induced liver injury is a devastating and fatal disease. Hydrogen is a newly-developed antioxidant that has an obvious effect of selectively reducing the strongest oxidants, such as hydroxyl radicals and peroxynitrite. We launched a research study to evaluate the protective role of hydrogen-rich water on APAP-induced hepatotoxicity in mice. We found that hydrogen-rich water treatment was effective in counteracting APAP-induced hepatic damage, oxidative stress and cellular necrosis. It could also promote hepatocyte proliferation and inhibit the expression of connexin 32, cytochrome P4502E and JNK phosphorylation after APAP administration. These results provide a potential therapy for APAP-induced liver injury. |
| Publish Date |
2015-04-15 11:01 |
| Citation |
Zhang JY, Song SD, Pang Q, Zhang RY, Wan Y, Yuan DW, Wu QF, Liu C. Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice. World J Gastroenterol 2015; 21(14): 4195-4209 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i14/4195.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i14.4195 |
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