Publication Name	World Journal of Experimental Medicine
Manuscript ID	14666
Country	France

Received	2014-10-18 12:08
Peer-Review Started	2014-10-18 12:30
To Make the First Decision	2014-11-14 19:15
Return for Revision	2014-11-20 08:35
Revised	2014-11-25 22:08
Second Decision	2014-12-15 08:25
Accepted by Journal Editor-in-Chief	2014-12-15 08:35
Accepted by Executive Editor-in-Chief	2014-12-19 17:52
Articles in Press	2014-12-19 17:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-19 13:59
Publish the Manuscript Online	2015-01-20 21:05

ISSN	2220-315x (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Engineering, Biomedical
Manuscript Type	Minireviews
Article Title	Internal ribosome entry site-based vectors for combined gene therapy
Manuscript Source	Invited Manuscript
All Author List	Edith Renaud-Gabardos, Fransky Hantelys, Florent Morfoisse, Xavier Chaufour, Barbara Garmy-Susini and Anne-Catherine Prats
Funding Agency and Grant Number
Corresponding Author	Anne-Catherine Prats, PhD, Université de Toulouse, UPS, TRADGENE, EA 4554, I2MC, 1, Avenue Jean Poulhes, BP 84225, 31432 Toulouse cedex 4, F-31432 Toulouse, France. anne-catherine.prats@inserm.fr
Key Words	Vector; Gene transfer; Internal ribosome entry site; Gene therapy
Core Tip	Combined gene therapy has emerged for a few years as a promising strategy to improve treatments of many diseases including cancer, cardiovascular diseases and degenerative diseases. In this context, internal ribosome entry site (IRES)-based vectors provide a powerful system to co-express several therapeutic genes from the same transcription unit. IRESs are translational enhancers, exhibiting tissue-specificity, and activated by stress. Different IRES-based vectors including plasmids, adeno-associated virus-derived and lentiviral vectors have been used successfully in many preclinical protocols of gene therapy. Moreover the few clinical assays launched with IRES-based multicistronic vectors resulted in therapeutic benefits.
Publish Date	2015-01-20 21:05
Citation	Renaud-Gabardos E, Hantelys F, Morfoisse F, Chaufour X, Garmy-Susini B, Prats AC. Internal ribosome entry site-based vectors for combined gene therapy. World J Exp Med 2015; 5(1): 11-20
URL	http://www.wjgnet.com/2220-315X/full/v5/i1/11.htm
DOI	http://dx.doi.org/10.5493/wjem.v5.i1.11

Full Article (PDF)	WJEM-5-11.pdf
Full Article (Word)	WJEM-5-11.doc
Manuscript File	14666-Review.doc
Answering Reviewers	14666-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14666-Conflict-of-interest statement.pdf
Copyright License Agreement	14666-Copyright assignment.pdf
Peer-review Report	14666-Peer review(s).pdf
Scientific Misconduct Check	14666-CrossCheck.jpg
Scientific Editor Work List	14666-Scientific editor work list.pdf