Publication Name	World Journal of Cardiology
Manuscript ID	14674
Country	Taiwan

Received	2014-10-20 09:38
Peer-Review Started	2014-10-22 08:11
To Make the First Decision	2015-02-07 15:03
Return for Revision	2015-02-10 15:25
Revised	2015-02-21 11:19
Second Decision	2015-03-16 17:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-04-07 15:53
Articles in Press	2015-04-07 15:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-09 16:12
Publish the Manuscript Online	2015-06-25 15:27

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Medicine, Research & Experimental
Manuscript Type	Editorial
Article Title	Perspective of future drugs targeting sterile 20/SPS1-related proline/alanine-rich kinase for blood pressure control
Manuscript Source	Invited Manuscript
All Author List	Gen-Min Lin, Pang-Yen Liu, Ching-Fen Wu, Wen-Been Wang and Chih-Lu Han
Funding Agency and Grant Number
Corresponding Author	Gen-Min Lin, MD, Department of Medicine, Hualien Armed Forces General Hospital, No.163, Jiali Rd., Xincheng Township, Hualien County 97144, Hualien 971, Taiwan. farmer507@yahoo.com.tw
Key Words	With-no-lysine (K) kinase; Oxidative stress-responsive kinase 1/SPS1-related proline/alanine-rich kinase kinase; Na-Cl co-transporter; Na+-K+-2Cl(-) cotransporter; Hypertension
Core Tip	According to a genome-wide association study, intronic SNPs within the human sterile 20/SPS1-related proline/alanine-rich kinase (SPAK) gene was linked to 20% of the general population and may be associated with elevated blood pressure. Based on current studies, targeting of SPAK seems to be promising for future antihypertensive therapy. Therefore, we raised some viewpoints regarding the issue for antihypertensive therapy on the SPAK (gene or kinase).
Publish Date	2015-06-25 15:27
Citation	Lin GM, Liu PY, Wu CF, Wang WB, Han CL. Perspective of future drugs targeting sterile 20/SPS1-related proline/alanine-rich kinase for blood pressure control. World J Cardiol 2015; 7(6): 306-310
URL	http://www.wjgnet.com/1949-8462/full/v7/i6/306.htm
DOI	http://dx.doi.org/10.4330/wjc.v7.i6.306

Full Article (PDF)	WJC-7-306.pdf
Manuscript File	14674-Review.docx
Answering Reviewers	14674-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14674-Conflict-of-interest statement.pdf
Copyright License Agreement	14674-Copyright assignment.pdf
Peer-review Report	14674-Peer-review(s).pdf
Scientific Misconduct Check	14674-Scientific misconduct check.pdf
Scientific Editor Work List	14674-Scientific editor work list.pdf