Publication Name	World Journal of Gastroenterology
Manuscript ID	14687
Country	China

Received	2014-10-20 08:46
Peer-Review Started	2014-10-20 19:08
To Make the First Decision	2014-12-26 13:27
Return for Revision	2014-12-28 17:42
Revised	2015-01-05 19:14
Second Decision	2015-02-11 22:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-12 17:38
Articles in Press	2015-02-13 11:22
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-03-13 08:21
Typeset the Manuscript	2015-05-25 14:17
Publish the Manuscript Online	2015-06-11 10:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Proportions of acetyl-histone-positive hepatocytes indicate the functional status and prognosis of cirrhotic patients
Manuscript Source	Unsolicited Manuscript
All Author List	Ping Zhou, Jie Xia, Yong-Jie Zhou, Jun Wan, Li Li, Ji Bao, Yu-Jun Shi and Hong Bu
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of China 81170424
Corresponding Author	Yu-Jun Shi, MD, PhD, Laboratory of Pathology, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu 610041, Sichuan Province, China. shiyujun@scu.edu.cn
Key Words	Histone acetylation; Cirrhosis; Liver function; Prognosis
Core Tip	We previously divided hepatocytes into transcriptionally active and inactive cells based on their immunoreactivity to acetyl-histones. In the present study, we evaluated the expression of acetyl-histone markers in livers with progressive cirrhosis to investigate whether inactive hepatocytes can be activated for functional compensation and act as markers of liver function. We found that the proportions of acetyl-histone-positive hepatocytes were associated with liver function, which revealed a regeneration-independent compensatory mechanism of chronically damaged liver. In addition, assaying the proportions of acetyl-histone-positive hepatocytes may offer a novel strategy for evaluating patient liver function and prognosis.
Publish Date	2015-06-11 10:11
Citation	Zhou P, Xia J, Zhou YJ, Wan J, Li L, Bao J, Shi YJ, Bu H. Proportions of acetyl-histone-positive hepatocytes indicate the functional status and prognosis of cirrhotic patients. World J Gastroenterol 2015; 21(21): 6665-6674
URL	http://www.wjgnet.com/1007-9327/full/v21/i21/6665.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i21.6665

Full Article (PDF)	WJG-21-6665.pdf
Full Article (Word)	WJG-21-6665.doc
Manuscript File	14687-Review.docx
Answering Reviewers	14687-Answering reviewers.pdf
Biostatistics Review Certificate	14687-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	14687-Conflict-of-interest statement.pdf
Copyright License Agreement	14687-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	14687-Language certificate.pdf
Peer-review Report	14687-Peer-review(s).pdf
Scientific Misconduct Check	14687-Scientific misconduct check.pdf
Scientific Editor Work List	14687-Scientific editor work list.pdf