Publication Name	World Journal of Gastroenterology
Manuscript ID	14692
Country	United States

Received	2014-10-20 10:07
Peer-Review Started	2014-10-21 08:59
To Make the First Decision	2014-11-14 18:46
Return for Revision	2014-11-18 18:36
Revised	2014-12-02 03:36
Second Decision	2015-01-23 16:36
Accepted by Journal Editor-in-Chief	2015-01-25 23:02
Accepted by Company Editor-in-Chief	2015-01-30 18:23
Articles in Press	2015-01-30 18:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-08 18:17
Publish the Manuscript Online	2015-03-19 16:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Hyponatremia in cirrhosis: Pathophysiology and management
Manuscript Source	Invited Manuscript
All Author List	Savio John and Paul J Thuluvath
Funding Agency and Grant Number
Corresponding Author	Paul J Thuluvath, MD, FAASLD, FRCP, Professor of Medicine and Surgery, University of Maryland School of Medicine and Mercy Medical Center, 301 Saint Paul Place, Baltimore, MD 21202, United States. thuluvath@gmail.com
Key Words	Hyponatremia in cirrhosis; Dilutional hyponatremia; Hypervolemic hyponatremia; Vasopressin receptor antagonists; Vaptans
Core Tip	Hyponatremia is the most common electrolyte abnormality observed in hospitalized patients and is a common finding in patients with advanced cirrhosis. The management of hyponatremia in cirrhosis is challenging as conventional therapy for hyponatremia including fluid restriction and loop diuretics are frequently inefficacious. Vaptans, drugs that selectively antagonizes the effects of arginine vasopressin on the V2 receptors in the kidney tubules, represent a logical step in the treatment of hyponatremia. The currently available vaptans, however, are not approved for use in patients with cirrhosis due to the increased risk for hepatic failure and mortality.
Publish Date	2015-03-19 16:57
Citation	John S, Thuluvath PJ. Hyponatremia in cirrhosis: Pathophysiology and management. World J Gastroenterol 2015; 21(11): 3197-3205
URL	http://www.wjgnet.com/1007-9327/full/v21/i11/3197.htm
DOI	http://www.wjgnet.com/1007-9327/full/v21/i11/3197.htm

Manuscript File	14692-Reciew.doc
Answering Reviewers	14692-Answering reviewers.pdf
Copyright License Agreement	14692-Copyright assignment.pdf
Peer-review Report	14692-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	14692-Journal Editor-in-Chief's Review Report.pdf
Scientific Misconduct Check	14692-CrossCheck.jpg
Scientific Editor Work List	14692-Scientific editor work list.pdf