Publication Name	World Journal of Cardiology
Manuscript ID	14759
Country	Netherlands

Received	2014-10-23 09:34
Peer-Review Started	2014-10-23 17:41
To Make the First Decision	2014-11-27 11:46
Return for Revision	2014-11-28 10:53
Revised	2014-12-26 00:00
Second Decision	2015-02-04 11:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-02-11 16:18
Articles in Press	2015-02-11 16:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-04 13:49
Publish the Manuscript Online	2015-05-21 13:54

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Editorial
Article Title	Pulmonary hypertension in hereditary haemorrhagic telangiectasia
Manuscript Source	Invited Manuscript
All Author List	Veronique MM Vorselaars, Sebastiaan Velthuis, Repke J Snijder, Jan Albert Vos, Johannes J Mager and Martijn C Post
Funding Agency and Grant Number
Corresponding Author	Veronique MM Vorselaars, MD, Department of Cardiology, St. Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands. m.post@antoniusziekenhuis.nl
Key Words	Hereditary haemorrhagic telangiectasia; High cardiac output; Pulmonary arterial hypertension; ENG; ACRVL1; Pulmonary hypertension
Core Tip	Pulmonary hypertension (PH) is increasingly recognised as a severe complication of hereditary haemorrhagic telangiectasia (HHT), but the true prevalence of PH in HHT is not known. Post-capillary PH most often results from the high cardiac output associated with hepatic arteriovenous malformations. More rarely the HHT gene mutations (ACRVL1 or ENG) result in pre-capillary pulmonary arterial hypertension (PAH). Differentiation between post-capillary PH en pre-capillary PAH can be done by right heart catheterisation, and is of importance since both entities are associated with severe morbidity and mortality and have different options for treatments.
Publish Date	2015-05-21 13:54
Citation	Vorselaars VMM, Velthuis S, Snijder RJ, Vos JA, Mager JJ, Post MC. Pulmonary hypertension in hereditary haemorrhagic telangiectasia. World J Cardiol 2015; 7(5): 230-237
URL	http://www.wjgnet.com/1949-8462/full/v7/i5/230.htm
DOI	http://dx.doi.org/10.4330/wjc.v7.i5.230

Full Article (PDF)	WJC-7-230.pdf
Full Article (Word)	WJC-7-230.doc
Manuscript File	14759-Review.doc
Answering Reviewers	14759-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14759-Conflict-of-interest statement.pdf
Copyright License Agreement	14759-Copyright assignment.pdf
Peer-review Report	14759-Peer-review(s).pdf
Scientific Misconduct Check	14759-Scientific misconduct check.pdf
Scientific Editor Work List	14759-Scientific editor work list.pdf