Publication Name	World Journal of Gastroenterology
Manuscript ID	1476
Country	China

Received	2012-12-13 21:21
Peer-Review Started	2012-12-16 12:51
To Make the First Decision	2012-12-28 17:56
Return for Revision	2012-12-30 22:20
Revised	2013-01-09 19:31
Second Decision	2013-03-06 17:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-03-07 07:28
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-05-03 15:37
Typeset the Manuscript	2013-05-20 09:40
Publish the Manuscript Online	2013-06-04 12:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Genetics & Heredity
Manuscript Type	Autobiography
Article Title	PRSS1_p.Leu81Met mutation results in autoimmune pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Feng Gao, Yue-Ming Li, Guo-Lin Hong, Zhi-Feng Xu, Qi-Cai Liu, Qing-Liang He, Li-Qing Lin and Shao-Huang Weng
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81201362 National Natural Science Foundation of China 81201590 National Natural Science Foundation of China 21275028 Putian Municipal Science and Technology Bureau Project 2009S3-3 Fujian Medical Innovations 2012-CXB-21 Education Department of Fujian Province JA12133 Education Department of Fujian Province JA12143 National High Technology Investigation Project Foundation of China 2012AA022604
Corresponding Author	Qi-Cai Liu, MD, Department of Laboratory Medicine, the First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou 350005, Fujian Province, China. lqc673673673@163.com
Key Words	Autoimmune pancreatitis; Molecular mechanism; p.81Leu→Met; PRSS1
Core Tip	Novel mutations (p.81Leu→Met and p.91Ala→Ala) were found in protease serine 1 gene from the patients with autoimmune pancreatitis. Trypsinogen abnormal activation resulted in multiple organ injuries. And this offers direct evidence in support of the trypsinogen gene mutation and abnormal immune system.
Publish Date	2013-06-04 12:34
Citation	Gao F, Li YM, Hong GL, Xu ZF, Liu QC, He QL, Lin LQ, Weng SH. PRSS1_p.Leu81Met mutation results in autoimmune pancreatitis. World J Gastroenterol 2013; 19(21): 3332-3338
URL	http://www.wjgnet.com/1007-9327/full/v19/i21/3332.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i21.3332

Full Article (PDF)	WJG-19-3332.pdf
Manuscript File	1476-Review.doc
Answering Reviewers	1476-Answering reviewers.doc
Copyright License Agreement	1476-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	1476-Language certificate.pdf
Peer-review Report	1476-Peer review(s).docx
Scientific Editor Work List	1476-Scientific editor work list.doc