Publication Name	World Journal of Meta-Analysis
Manuscript ID	14764
Country	United States

Received	2014-10-23 08:53
Peer-Review Started	2014-10-24 17:36
To Make the First Decision	2014-12-26 13:14
Return for Revision	2014-12-30 16:12
Revised	2015-01-03 01:49
Second Decision	2015-01-08 17:01
Accepted by Journal Editor-in-Chief	2015-01-10 07:41
Accepted by Executive Editor-in-Chief	2015-01-19 13:41
Articles in Press	2015-01-19 13:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-02-06 14:05
Publish the Manuscript Online	2015-04-28 10:11

ISSN	2308-3840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Meta-analysis of single strain probiotics for the eradication of Helicobacter pylori and prevention of adverse events
Manuscript Source	Invited Manuscript
All Author List	Lynne V McFarland, Peter Malfertheiner, Ying Huang and Lin Wang
Funding Agency and Grant Number
Corresponding Author	Lynne V McFarland, PhD, Health Services Research and Development, VA Puget Sound Health Care System, Department of Veterans Affairs, Metropolitan Park West, 1100 Olive Way #1400, Seattle, WA 98101, United States. lvmcfarl@u.washington.edu
Key Words	Probiotics; Safety; Saccharomyces boulardii; Helicobacter pylori; Meta-analysis; Adverse reactions; Diarrhea; Lactobacillus rhamnosus; Randomized clinical trials
Core Tip	A meta-analysis was conducted (1960-2014) for randomized clinical trials testing single strained probiotics as an adjunct to standard Helicobacter pylori (H. pylori) eradication therapy. Of the single strains with multiple trials, only one significantly improved H. pylori eradication rates {Saccharomyces boulardii (S. boulardii) I-745 [pooled relative risks (pRR) = 1.11, 95%CI: 1.07-1.16)]}, while two strains significantly reduced the rate of antibiotic-associated diarrhea [S. boulardii I-745 (pRR = 0.47, 95%CI: 0.37-0.60) and Lactobacillus rhamnosus GG (pRR = 0.29, 95%CI: 0.17-0.48)]. None of the other four probiotic strains improved H. pylori therapy (C. butyricum, L. acidophilus, L. reuteri, L. casei).
Publish Date	2015-04-28 10:11
Citation	McFarland LV, Malfertheiner P, Huang Y, Wang L. Meta-analysis of single strain probiotics for the eradication of Helicobacter pylori and prevention of adverse events. World J Meta-Anal 2015; 3(2): 97-117
URL	http://www.wjgnet.com/2308-3840/full/v3/i2/97.htm
DOI	http://dx.doi.org/10.13105/wjma.v3.i2.97

Full Article (PDF)	WJMA-3-97.pdf
Full Article (Word)	WJMA-3-97.doc
Manuscript File	14764-Review.docx
Answering Reviewers	14764-Answering reviewers.pdf
Biostatistics Review Certificate	14764-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	14764-Conflict-of-interest statement.pdf
Copyright License Agreement	14764-Copyright assignment.pdf
Supplementary Material	First pages of References with no DOI PMID.pdf
Peer-review Report	14764-Peer review(s).pdf
Scientific Misconduct Check	14764-CrossCheck.jpg
Scientific Editor Work List	14764-Scientific editor work list.pdf