Publication Name	World Journal of Cardiology
Manuscript ID	14775
Country	Poland

Received	2014-10-23 19:28
Peer-Review Started	2014-10-24 10:50
To Make the First Decision	2014-12-26 13:14
Return for Revision	2014-12-30 16:32
Revised	2015-01-16 02:57
Second Decision	2015-01-28 11:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-09 10:02
Articles in Press	2015-02-09 10:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-03 17:15
Publish the Manuscript Online	2015-04-20 14:22

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Peripheral Vascular Disease
Manuscript Type	Editorial
Article Title	Helicobacter pylori vs coronary heart disease - searching for connections
Manuscript Source	Invited Manuscript
All Author List	Magdalena Chmiela, Adrian Gajewski and Karolina Rudnicka
Funding Agency and Grant Number
Corresponding Author	Magdalena Chmiela, Professor, Chief of Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Łódź, Banacha 12/16, 90-236 Łódź, Poland. chmiela@biol.uni.lodz.pl
Key Words	Helicobacter pylori; Coronary heart disease; Inflammation; Microbiota; Lipopolysaccharide
Core Tip	Helicobacter pylori (H. pylori) is a Gram-negative spiral bacterium which colonizes gastric mucosa of nearly half of human population. A charac-teristic feature of H. pylori infection is an excessive inflammatory response. The majority of H. pylori infections remain asymptomatic. However, still it leads to the development of histological gastritis with the recruitment of immune cells. About 10% of infected subjects develop symptomatic gastritis, erosions or peptic ulcer. Gastric cancer is the most severe consequence of H. pylori infection. Recently, a possible association between chronic infections with H. pylori and extragastric disorders - including coronary heart disease, has been intensively investigated. Here we have revised recent studies confirming or excluding possible connections between chronic bacterial infections and the occurrence of coronary heart disease (CHD) within different populations, especially in the context of H. pylori infections. We have also presented various study approaches investigating direct and indirect interplay between H. pylori-driven consequences and CHD development to clarify already gained knowledge and suggest future directions. Considering the significance of already conducted research studies, the involvement of H. pylori infection in the process of CHD development is highly probably, however, still a lot need to be done to clarify whether this association is direct (with the involvement of H. pylori antigens and products) or indirect (with the involvement of inflammatory-related molecules accelerating/initiating CHD development).
Publish Date	2015-04-20 14:22
Citation	Chmiela M, Gajewski A, Rudnicka K. Helicobacter pylori vs coronary heart disease - searching for connections. World J Cardiol 2015; 7(4): 187-203
URL	http://www.wjgnet.com/1949-8462/full/v7/i4/187.htm
DOI	http://dx.doi.org/10.4330/wjc.v7.i4.187

Full Article (PDF)	WJC-7-187.pdf
Full Article (Word)	WJC-7-187.doc
Manuscript File	14775-Review.doc
Answering Reviewers	14775-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14775-Conflict-of-interest statement.pdf
Copyright License Agreement	14775-Copyright assignment.pdf
Peer-review Report	14775-Peer-review(s).pdf
Scientific Misconduct Check	14775-Scientific misconduct check.pdf
Scientific Editor Work List	14775-Scientific editor work list.pdf