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Articles Published Processes
6/18/2015 5:31:00 PM | Browse: 1272 | Download: 2190
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Received |
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2014-10-24 08:46 |
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Peer-Review Started |
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2014-10-27 08:50 |
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To Make the First Decision |
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2014-11-14 18:43 |
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Return for Revision |
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2014-11-20 09:20 |
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Revised |
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2014-12-03 21:55 |
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Second Decision |
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2014-12-26 13:49 |
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Accepted by Journal Editor-in-Chief |
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2014-12-26 15:00 |
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Accepted by Executive Editor-in-Chief |
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2015-02-13 09:07 |
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Articles in Press |
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2015-02-13 11:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-03-18 21:01 |
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Typeset the Manuscript |
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2015-05-31 18:28 |
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Publish the Manuscript Online |
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2015-06-18 17:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sevil Uygun Ilikhan, Muammer Bilici, Hatice Sahin, Ayşe Semra Demir Akca, Murat Can, Ibrahim Ilker Oz, Berrak Guven, M Cagatay Buyukuysal and Yucel Ustundag |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dr. Ayşe Semra Demir Akca, Department of Family Medicine, Bülent Ecevit University Faculty of Medicine, Esenköy, Kozlu, Zonguldak 67100, Turkey. aysesemra@hotmail.com |
| Key Words |
Alpha-fetoprotein; Hepatocellular carcinoma; Prolidase; Cirrhosis; Macrovascular invasion |
| Core Tip |
Prolidase cleaves dipeptide bonds containing proline, playing a vital role in collagen turnover, matrix remodeling and cell growth. Neoplastic transformation results in deregulation of tissue collagen metabolism, in which metastatic tumor cells produce enhanced amounts of proteases to penetrate basement membranes and the extracellular matrix. Therefore, tumor progression might depend on the breakdown of collagen and other extracellular matrix proteins. The role of prolidase in neoplastic tissues is unknown. Herein, serum prolidase levels in hepatocellular carcinoma (HCC) patients were significantly associated with tumor size and number, Barcelona-clinic liver cancer staging and alpha-fetoprotein (AFP). Considering the levels of both serum prolidase and AFP could contribute to early diagnosis of HCC. |
| Publish Date |
2015-06-18 17:32 |
| Citation |
Uygun Ilikhan S, Bilici M, Sahin H, Demir Akca AS, Can M, Oz II, Guven B, Buyukuysal MC, Ustundag Y. Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma. World J Gastroenterol 2015; 21(22): 6999-7007 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i22/6999.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i22.6999 |
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