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Articles Published Processes
4/30/2015 2:11:00 PM | Browse: 1027 | Download: 1777
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Received |
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2014-10-24 17:49 |
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Peer-Review Started |
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2014-10-25 19:30 |
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To Make the First Decision |
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2014-11-14 18:42 |
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Return for Revision |
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2014-11-18 20:48 |
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Revised |
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2014-12-09 18:35 |
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Second Decision |
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2015-01-28 14:10 |
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Accepted by Journal Editor-in-Chief |
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2015-01-29 00:09 |
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Accepted by Company Editor-in-Chief |
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2015-01-30 15:38 |
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Articles in Press |
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2015-01-30 18:32 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-03-14 18:24 |
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Typeset the Manuscript |
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2015-04-01 12:21 |
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Publish the Manuscript Online |
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2015-04-20 15:10 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Basic Study |
| Article Title |
Tong Xie Yao Fang relieves irritable bowel syndrome in rats by mechanisms involving regulations of 5-hydroxytryptamine and substance P
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yue Yin, Lei Zhong, Jian-Wei Wang, Xue-Ying Zhao, Wen-Jing Zhao and Hai-Xue Kuang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Education Department “ChunHui Plan” Research Projects |
Z2010021 |
| China Postdoctoral Science Foundation Project |
2013M531079 |
| Heilongjiang Postdoctoral Funding Project |
LBH-Z12246 |
| Heilongjiang Education Department Scientific Research Project |
12521502 |
| Excellent Innovative Talents Support Program Funding of Heilongjiang University of Chinese Medicine |
051217 |
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| Corresponding Author |
Jian-Wei Wang, Associate Professor, Chinese Medicine Teaching and Research Office, Basic Medical College, Heilongjiang University of Chinese Medicine, No. 24, Heping Road, Harbin 150040, Heilongjiang Province, China. wangjianwei140918@126.com |
| Key Words |
Tong Xie Yao Fang; Irritable bowel syndrome; 5-hydroxytryptamine; Substance P; Traditional Chinese medicine |
| Core Tip |
Baby rats separating from mother rats (1 h per day) and rectum expanded with angioplasty were carried out to establish rat irritable bowel syndrome (IBS) model. We examined the ability of the traditional Chinese medicine Tong Xie Yao Fang (TXYF) to improve the dysfunction of gastrointestinal motility in IBS rats. The effects of TXYF on defecation frequency and colonic motility were analyzed by recording contractions of colon smooth muscle and measurement of genes that express 5-hydroxytryptamine and substance P. Exogenous stimulants increased spontaneous activity and elicited contractions of colon smooth muscle in IBS model rats, which were significantly reduced by TXYF. |
| Publish Date |
2015-04-20 15:10 |
| Citation |
Yin Y, Zhong L, Wang JW, Zhao XY, Zhao WJ, Kuang HX. Tong xie yao fang relieves irritable bowel syndrome in rats via mechanisms involving regulation of 5-hydroxytryptamine and substance P. World J Gastroenterol 2015; 21(15): 4536-4546 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i15/4536.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i15.4536 |
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