Publication Name	World Journal of Gastroenterology
Manuscript ID	14791
Country	China

Received	2014-10-24 17:51
Peer-Review Started	2014-10-25 17:06
To Make the First Decision	2014-12-26 13:32
Return for Revision	2015-01-05 08:56
Revised	2015-01-19 10:35
Second Decision	2015-02-10 21:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-11 15:02
Articles in Press	2015-02-11 16:11
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-04-07 17:48
Typeset the Manuscript	2015-04-21 10:34
Publish the Manuscript Online	2015-05-13 10:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Methodology
Manuscript Type	Review
Article Title	From reflux esophagitis to Barrett’s esophagus and esophageal adenocarcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Rui-Hua Wang
Funding Agency and Grant Number	Funding Agency Grant Number Shanghai Fengxian District of Science and Technology Commission 20131203
Corresponding Author	Rui-Hua Wang, MD, Department of Gastroenterology, Shanghai Jiao Tong University affiliated Sixth People’s Hospital South Campus, No. 6600 Nanfeng Road, Fengxian District, Shanghai 201499, China. ruihuawang@sina.cn
Key Words	Animal models; Gastroesophageal reflux disease; Reflux esophagitis; Barrett’s esophagus; Esophageal adenocarcinoma
Core Tip	Various modeling methods are reviewed and major findings on the developmental mechanism of Barrett’s esophagus are discussed, with the aim of identifying better prevention and treatment strategies for Barrett’s esophagus. Chronic exposure of the esophagus to gastroduodenal intestinal fluid is an important determinant factor in the development of Barrett’s esophagus. However, the exact mechanism of injury is not completely understood. Various animal models have been widely used in research. The advantage of using animal models in research lies in the ability to accurately control the experimental conditions for better evaluation of results.
Publish Date	2015-05-13 10:38
Citation	Wang RH. From reflux esophagitis to Barrett’s esophagus and esophageal adenocarcinoma. World J Gastroenterol 2015; 21(17): 5210-5219
URL	http://www.wjgnet.com/1007-9327/full/v21/i17/5210.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i17.5210

Full Article (PDF)	WJG-21-5210.pdf
Full Article (Word)	WJG-21-5210.doc
Manuscript File	14791-Review.doc
Answering Reviewers	14791-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14791-Conflict-of-interest statement.pdf
Copyright License Agreement	14791-Copyright assignment.pdf
Peer-review Report	14791-Peer-review(s).pdf
Scientific Misconduct Check	14791-Scientific misconduct check.pdf
Scientific Editor Work List	14791-Scientific editor work list.pdf