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Articles Published Processes
4/15/2015 11:01:00 AM | Browse: 1179 | Download: 2430
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Received |
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2014-10-27 08:51 |
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Peer-Review Started |
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2014-10-28 14:51 |
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To Make the First Decision |
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2014-11-14 18:42 |
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Return for Revision |
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2014-11-18 20:58 |
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Revised |
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2014-11-27 16:33 |
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Second Decision |
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2015-01-07 09:09 |
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Accepted by Journal Editor-in-Chief |
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2015-01-07 16:26 |
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Accepted by Executive Editor-in-Chief |
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2015-01-16 18:03 |
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Articles in Press |
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2015-01-16 18:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-01-23 18:10 |
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Typeset the Manuscript |
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2015-03-31 11:37 |
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Publish the Manuscript Online |
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2015-04-15 11:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Th22 cell accumulation is associated with colorectal cancer development
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yong-Hong Huang, Yun-Fei Cao, Zhi-Yuan Jiang, Sen Zhang and Feng Gao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81260316 |
| National Natural Science Foundation of China |
81260335 |
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| Corresponding Author |
Feng Gao, Professor, Department of Colorectal and Anal Surgery, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. doctorgao0771@hotmail.com |
| Key Words |
Th22 cells; interleukin-22; STAT3; Colorectal cancer; Tumor microenvironment |
| Core Tip |
Although the functional characteristics of Th22 cells in inflammatory and autoimmune diseases have been extensively studied, their role in colorectal cancer (CRC) remains unclear. This study demonstrated the differences in the expression of Th22 cells and their related cytokines between colorectal tumor and paratumor tissues and the accumulation of Th22 cells in CRC may be associated with the functions of chemotactic factors that are secreted by the tumor microenvironment. interleukin-22 was found to be the functional factor of Th22 cells that is associated with CRC development in both in vitro and in vivo experiments, most likely via STAT3 pathway activation. |
| Publish Date |
2015-04-15 11:01 |
| Citation |
Huang YH, Cao YF, Jiang ZY, Zhang S, Gao F. Th22 cell accumulation is associated with colorectal cancer development. World J Gastroenterol 2015; 21(14): 4216-4224 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i14/4216.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i14.4216 |
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