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Articles Published Processes
3/13/2015 3:00:00 PM | Browse: 1252 | Download: 1486
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Received |
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2014-10-27 08:31 |
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Peer-Review Started |
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2014-10-28 08:14 |
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To Make the First Decision |
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2014-12-17 11:34 |
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Return for Revision |
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2014-12-22 09:43 |
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Revised |
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2015-01-05 21:33 |
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Second Decision |
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2015-01-14 08:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-01-20 16:49 |
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Articles in Press |
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2015-01-20 16:49 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-03-03 15:47 |
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Publish the Manuscript Online |
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2015-03-13 15:00 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Editorial |
| Article Title |
Making cardiomyocytes with your chemistry set: Small molecule-induced cardiogenesis in somatic cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Woong-Hee Kim, Da-Woon Jung and Darren Reece Williams |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation |
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| MEST Basic Science Research Program |
NRF-2012R1A1B5000462 (to D.-W.J） |
| Korean Health Technology R&D Project, Ministry of Health and Welfare, South Korea |
HI12C0275 |
| Bioimaging Center, Gwangju Institute of Science and Technology |
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| Corresponding Author |
Darren Reece Williams, PhD, New Drug Targets Laboratory, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712,
South Korea. darren@gist.ac.kr
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| Key Words |
Cardiogenesis; Cell reprogramming; Somatic cells; Small molecules; Cardiovascular disease |
| Core Tip |
There are a plethora of methods to manipulate the phenotype of somatic cells and convert them into different cell types, such as cardiac cells. The use of small molecules provides numerous advantages, such as ease of use, tight temporal control and reversible effects on target proteins. Significantly, the production of small molecules is cheap and synthesis can be readily standardized. This would allow non-specialist stem cell laboratories to readily adopt small molecule-based methods to produce functional cardiac cells from multiple cell sources, including therapeutic applications requiring the somatic cells of patients with cardiovascular disease. |
| Publish Date |
2015-03-13 15:00 |
| Citation |
Kim WH, Jung DW, Williams DR. Making cardiomyocytes with your chemistry set: Small molecule-induced cardiogenesis in somatic cells. World J Cardiol 2015; 7(3): 125-133 |
| URL |
http://www.wjgnet.com/1949-8462/full/v7/i3/125.htm |
| DOI |
http://dx.doi.org/10.4330/wjc.v7.i3.125 |
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