| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Randomized Clinical Trial |
| Article Title |
Effectiveness of probiotic therapy for the prevention of relapse in patients with inactive ulcerative colitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yasushi Yoshimatsu, Akihiro Yamada, Ryuichi Furukawa, Koji Sono, Aisaku Osamura, Kentaro Nakamura, Hiroshi Aoki, Yukiko Tsuda, Nobuo Hosoe, Nobuo Takada and Yasuo Suzuki |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Yasushi Yoshimatsu, Assistant Professor, Department of Internal Medicine, Faculty of Medicine, Toho University, Toho University Sakura Medical Center, 564-1, Shimoshizu, Sakura, Chiba 285-8741, Japan. 600184yy@sakura.med.toho-u.ac.jp |
| Key Words |
Ulcerative colitis; Probiotics; Inflammatory bowel disease; Cluster analysis |
| Core Tip |
We conducted a single-center, randomized, double-blind, placebo-controlled study to examine whether 12 mo of probiotic therapy was useful for preventing relapse of ulcerative colitis (UC) in patients who were already in remission. The relapse rates in the probiotic therapy group and placebo group were respectively 0.0% vs 17.4% at 3 mo (P = 0.036), 8.7% vs 26.1% at 6 mo (P = 0.119), and 21.7% vs 34.8% (P = 0.326) at 9 mo. At 12 mo, the remission rate was 69.5% in the probiotic therapy group and 56.6% in the placebo group (P = 0.248). Therefor probiotics may be effective for maintaining clinical remission in patients with quiescent UC. |
| Publish Date |
2015-05-20 17:01 |
| Citation |
Yoshimatsu Y, Yamada A, Furukawa R, Sono K, Osamura A, Nakamura K, Aoki H, Tsuda Y, Hosoe N, Takada N, Suzuki y. Effectiveness of probiotic therapy for the prevention of relapse in patients with inactive ulcerative colitis. World J Gastroenterol 2015; 21(19): 5985-5994 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i19/5985.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i19.5985 |
