Publication Name	World Journal of Gastroenterology
Manuscript ID	14848
Country	China

Received	2014-10-28 08:35
Peer-Review Started	2014-10-28 10:25
To Make the First Decision	2014-12-26 13:32
Return for Revision	2015-01-05 09:18
Revised	2015-01-26 19:33
Second Decision	2015-02-10 21:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-02-11 15:11
Articles in Press	2015-02-11 16:14
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-05-21 23:44
Typeset the Manuscript	2015-05-27 20:03
Publish the Manuscript Online	2015-06-20 17:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Association between polymorphism of beta-2 adrenergic receptor gene and response to propranolol in cirrhosis
Manuscript Source	Unsolicited Manuscript
All Author List	De-Run Kong, Jin-Guang Wang, Bin Sun, Ming-Quan Wang, Chen Chen, Fang-Fang Yu and Jian-Ming Xu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81271736
Corresponding Author	De-Run Kong, MD, Professor, Department of Gastroenterology, the first Affiliated Hospital of Anhui Medical University, 218 JiXi Road, Hefei 230022, Anhui Province, China. kongderun@ahmu.edu.cn
Key Words	Variceal bleeding; β2-adrenergic receptor; Propranolol; Variceal pressure; Homozygotes
Core Tip	The study explored the influence of beta-2 adrenergic receptor (β2-AR) polymorphism and the response of esophageal variceal pressure to chronic treatment with propranolol. The originality was that we associated the polymorphism to the measurement of variceal pressure and considered the response to propranolol administration. We found that the variceal pressure response to propranolol was associated with β2-AR gene polymorphisms, and that the patients with the Gly16-Glu/Gln27 homozygotes seem to benefit more from propranolol therapy.
Publish Date	2015-06-20 17:38
Citation	Kong DR, Wang JG, Sun B, Wang MQ, Chen C, Yu FF, Xu JM. β-2 Adrenergic receptor gene polymorphism and response to propranolol in cirrhosis. World J Gastroenterol 2015; 21(23): 7191-7196
URL	http://www.wjgnet.com/1007-9327/full/v21/i23/7191.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i23.7191

Full Article (PDF)	WJG-21-7191.pdf
Full Article (Word)	WJG-21-7191.doc
Manuscript File	14848-Review.doc
Answering Reviewers	14848-Answering reviewers.pdf
Copyright License Agreement	14848-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	14848-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	14848-Language cetificate.pdf
Peer-review Report	14848-Peer-review(s).pdf
Scientific Misconduct Check	14848-Scientific misconduct check.pdf
Scientific Editor Work List	14848-Scientific editor work list.pdf