Publication Name	World Journal of Gastroenterology
Manuscript ID	14876
Country	United Kingdom

Received	2014-10-29 09:05
Peer-Review Started	2014-10-29 19:24
To Make the First Decision	2014-12-11 20:20
Return for Revision	2014-12-24 09:38
Revised	2015-01-10 01:09
Second Decision	2015-02-10 21:16
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-11 15:14
Articles in Press	2015-02-11 16:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-25 21:02
Publish the Manuscript Online	2015-07-08 12:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Clinical predictors of thiopurine-related adverse events in Crohn's disease
Manuscript Source	Unsolicited Manuscript
All Author List	Gordon W Moran, Marie-France Dubeau, Gilaad G Kaplan, Hong Yang, Bertus Eksteen, Subrata Ghosh and Remo Panaccione
Funding Agency and Grant Number
Corresponding Author	Gordon W Moran, Clinical Associate Professor, Honorary Consultant Gastroenterologist, Nottingham Digestive Diseases Centre, Biomedical Research Unit, University of Nottingham, Queen’s Medical Centre, E floor, West Block, NG7 2UH Nottingham, United Kingdom. gordon.moran@nottingham.ac.uk
Key Words	Thiopurines; Azathioprine; Mercaptopurine; Adverse events
Core Tip	In Crohn’s disease, adverse events to thiopu?rines are a common occurrence leading to discontinuation of therapy in 1 in 3 patients in this referral centre cohort. Adverse events leading to discontinuation of the drug were significantly more common in female patients over the age of 40 years at drug prescription. These findings should be replicated in other centres, in other clinical indications for thiopurine use and correlated to thiopurine 6-methyltransferase genotype, activity and thiopurine metabolities.
Publish Date	2015-07-08 12:01
Citation	Moran GW, Dubeau MF, Kaplan GG, Yang H, Eksteen B, Ghosh S, Panaccione R. Clinical predictors of thiopurine-related adverse events in Crohn’s disease. World J Gastroenterol 2015; 21(25): 7795-7804
URL	http://www.wjgnet.com/1007-9327/full/v21/i25/7795.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i25.7795

Full Article (PDF)	WJG-21-7795.pdf
Full Article (Word)	WJG-21-7795.doc
Manuscript File	14876-Review.docx
Answering Reviewers	14876-Answering reviewers.pdf
Biostatistics Review Certificate	14876-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	14876-Conflict-of-interest statement.pdf
Copyright License Agreement	14876-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	14876-Institutional review board statement.pdf
Peer-review Report	14876-Peer-review(s).pdf
Scientific Misconduct Check	14876-Scientific misconduct check.pdf
Scientific Editor Work List	14876-Scientific editor work list.pdf