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5/13/2015 10:38:00 AM | Browse: 966 | Download: 1516
Publication Name World Journal of Gastroenterology
Manuscript ID 14896
Country/Territory China
Received
2014-10-29 08:12
Peer-Review Started
2014-10-29 19:38
To Make the First Decision
2014-12-26 13:32
Return for Revision
2015-01-05 09:28
Revised
2015-01-27 20:03
Second Decision
2015-02-10 21:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-02-11 15:15
Articles in Press
2015-02-11 16:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-03-17 19:20
Typeset the Manuscript
2015-04-19 18:03
Publish the Manuscript Online
2015-05-13 10:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Glycyrrhizic acid inhibits apoptosis and fibrosis in carbon-tetrachloride-induced rat liver injury
Manuscript Source Unsolicited Manuscript
All Author List Bo Liang, Xiao-Ling Guo, Jing Jin, Yong-Chun Ma and Zheng-Quan Feng
Funding Agency and Grant Number
Funding Agency Grant Number
Medical and Health Science and Technology Planning Project of Zhejiang Province in 2012, China 2012RCB007
Corresponding Author Yong-Chun Ma, MD, Department II of Psychosomatics, Tongde Hospital of Zhejiang Province, No. 234 Gucui Road, Hangzhou 310012, Zhejiang Province, China. tdxsk2015@163.com
Key Words Glycyrrhizic acid; Hepatocyte apoptosis; Liver fibrosis; Hepatic stellate cell; Matrix metalloproteinase
Core Tip This study showed that glycyrrhizic acid (GA) had inhibitory effects on hepatocyte apoptosis and liver fibrosis, which were mainly associated with down-regulation of hepatic stellate cell (HSC) activation, thus regulating fibrotic-related factors, such as expression levels of CTGF, MMP2 and MMP9 proteins, and collagen type Ⅰ and Ⅲ mRNA. Collectively, these results demonstrate that GA treatment significantly ameliorated CCl4-induced liver fibrosis by inhibiting hepatocyte apoptosis and HSC activation, which may provide potential therapeutic strategies for anti-fibrosis.
Publish Date 2015-05-13 10:38
Citation Liang B, Guo XL, Jin J, Ma YC, Feng ZQ. Glycyrrhizic acid inhibits apoptosis and fibrosis in carbon-tetrachloride-induced rat liver injury. World J Gastroenterol 2015; 21(17): 5271-5280
URL http://www.wjgnet.com/1007-9327/full/v21/i17/5271.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i17.5271
Full Article (PDF) WJG-21-5271.pdf
Full Article (Word) WJG-21-5271.doc
Manuscript File 14896-Review.doc
Answering Reviewers 14896-Answering reviewers.pdf
Copyright License Agreement 14896-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 14896-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 14896-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 14896-Language certificate.PDF
Peer-review Report 14896-Peer-review(s).pdf
Scientific Misconduct Check 14896-Scientific misconduct check.pdf
Scientific Editor Work List 14896-Scientific editor work list.pdf