Publication Name	World Journal of Gastroenterology
Manuscript ID	14896
Country	China

Received	2014-10-29 08:12
Peer-Review Started	2014-10-29 19:38
First Decision by Editorial Office Director
Return for Revision	2015-01-05 09:28
Revised	2015-01-27 20:03
Publication Fee Transferred
Second Decision by Editor	2015-02-10 21:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-02-11 15:15
Articles in Press	2015-02-11 16:15
Edit the Manuscript by Language Editor	2015-03-17 19:20
Typeset the Manuscript	2015-04-19 18:03
Publish the Manuscript Online	2015-05-13 10:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Glycyrrhizic acid inhibits apoptosis and fibrosis in carbon-tetrachloride-induced rat liver injury
Manuscript Source	Unsolicited Manuscript
All Author List	Bo Liang, Xiao-Ling Guo, Jing Jin, Yong-Chun Ma and Zheng-Quan Feng
Funding Agency and Grant Number	Funding Agency Grant Number Medical and Health Science and Technology Planning Project of Zhejiang Province in 2012, China 2012RCB007
Corresponding Author	Yong-Chun Ma, MD, Department II of Psychosomatics, Tongde Hospital of Zhejiang Province, No. 234 Gucui Road, Hangzhou 310012, Zhejiang Province, China. tdxsk2015@163.com
Key Words	Glycyrrhizic acid; Hepatocyte apoptosis; Liver fibrosis; Hepatic stellate cell; Matrix metalloproteinase
Core Tip	This study showed that glycyrrhizic acid (GA) had inhibitory effects on hepatocyte apoptosis and liver fibrosis, which were mainly associated with down-regulation of hepatic stellate cell (HSC) activation, thus regulating fibrotic-related factors, such as expression levels of CTGF, MMP2 and MMP9 proteins, and collagen type Ⅰ and Ⅲ mRNA. Collectively, these results demonstrate that GA treatment significantly ameliorated CCl4-induced liver fibrosis by inhibiting hepatocyte apoptosis and HSC activation, which may provide potential therapeutic strategies for anti-fibrosis.
Publish Date	2015-05-13 10:38
Citation	Liang B, Guo XL, Jin J, Ma YC, Feng ZQ. Glycyrrhizic acid inhibits apoptosis and fibrosis in carbon-tetrachloride-induced rat liver injury. World J Gastroenterol 2015; 21(17): 5271-5280
URL	http://www.wjgnet.com/1007-9327/full/v21/i17/5271.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i17.5271

Full Article (PDF)	WJG-21-5271.pdf
Full Article (Word)	WJG-21-5271.doc
Manuscript File	14896-Review.doc
Answering Reviewers	14896-Answering reviewers.pdf
Copyright License Agreement	14896-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	14896-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	14896-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	14896-Language certificate.PDF
Peer-review Report	14896-Peer-review(s).pdf
Scientific Misconduct Check	14896-Scientific misconduct check.pdf
Scientific Editor Work List	14896-Scientific editor work list.pdf