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Articles Published Processes
5/13/2015 10:38:00 AM | Browse: 1087 | Download: 1854
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Received |
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2014-10-29 08:12 |
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Peer-Review Started |
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2014-10-29 19:38 |
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To Make the First Decision |
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2014-12-26 13:32 |
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Return for Revision |
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2015-01-05 09:28 |
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Revised |
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2015-01-27 20:03 |
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Second Decision |
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2015-02-10 21:17 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-02-11 15:15 |
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Articles in Press |
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2015-02-11 16:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-03-17 19:20 |
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Typeset the Manuscript |
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2015-04-19 18:03 |
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Publish the Manuscript Online |
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2015-05-13 10:38 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Glycyrrhizic acid inhibits apoptosis and fibrosis in carbon-tetrachloride-induced rat liver injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bo Liang, Xiao-Ling Guo, Jing Jin, Yong-Chun Ma and Zheng-Quan Feng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Medical and Health Science and Technology Planning Project of Zhejiang Province in 2012, China |
2012RCB007 |
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| Corresponding Author |
Yong-Chun Ma, MD, Department II of Psychosomatics, Tongde Hospital of Zhejiang Province, No. 234 Gucui Road, Hangzhou 310012, Zhejiang Province, China. tdxsk2015@163.com |
| Key Words |
Glycyrrhizic acid; Hepatocyte apoptosis; Liver fibrosis; Hepatic stellate cell; Matrix metalloproteinase |
| Core Tip |
This study showed that glycyrrhizic acid (GA) had inhibitory effects on hepatocyte apoptosis and liver fibrosis, which were mainly associated with down-regulation of hepatic stellate cell (HSC) activation, thus regulating fibrotic-related factors, such as expression levels of CTGF, MMP2 and MMP9 proteins, and collagen type Ⅰ and Ⅲ mRNA. Collectively, these results demonstrate that GA treatment significantly ameliorated CCl4-induced liver fibrosis by inhibiting hepatocyte apoptosis and HSC activation, which may provide potential therapeutic strategies for anti-fibrosis. |
| Publish Date |
2015-05-13 10:38 |
| Citation |
Liang B, Guo XL, Jin J, Ma YC, Feng ZQ. Glycyrrhizic acid inhibits apoptosis and fibrosis in carbon-tetrachloride-induced rat liver injury. World J Gastroenterol 2015; 21(17): 5271-5280 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i17/5271.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i17.5271 |
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