Publication Name	World Journal of Gastroenterology
Manuscript ID	14908
Country	China

Received	2014-10-30 08:31
Peer-Review Started	2014-10-30 16:14
First Decision by Editorial Office Director
Return for Revision	2014-12-24 09:04
Revised	2015-01-08 23:36
Publication Fee Transferred
Second Decision by Editor	2015-04-07 17:33
Second Decision by Editor-in-Chief	2015-04-08 05:33
Final Decision by Editorial Office Director	2015-04-09 16:56
Articles in Press	2015-04-09 17:17
Edit the Manuscript by Language Editor	2015-04-28 13:40
Typeset the Manuscript	2015-06-16 09:53
Publish the Manuscript Online	2015-06-20 17:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Activated rat hepatic stellate cells influence Th1/Th2 profile in vitro
Manuscript Source	Unsolicited Manuscript
All Author List	Zhi-Zhi Xing, Liu-Ye Huang, Cheng-Rong Wu, Hong You, Hong Ma and Ji-Dong Jia
Funding Agency and Grant Number	Funding Agency Grant Number Major State Basic Research Development Program of China 2007CB512802 National Natural Science Foundation of China 30500425
Corresponding Author	Ji-Dong Jia, MD, PhD, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, 95 Yong-an Road, Xicheng District, Beijing 100050, China. jiamd@263.net
Key Words	Hepatic stellate cells; Th1 cells; Th2 cells; Galectin-9
Core Tip	The Th1/Th2 profile plays a pivotal role in the development of fibrosis, and may be impacted by hepatic stellate cell activation. However, little is known about the effect of fibroblasts on CD4+ T lymphocyte profiles. This study shows that co-culture with activated rat hepatic stellate cells shifts the Th1/Th2 profile of CD4+ T lymphocytes by inhibiting the Th1 response and enhancing the Th2 response.
Publish Date	2015-06-20 17:38
Citation	Xing ZZ, Huang LY, Wu CR, You H, Ma H, Jia JD. Activated rat hepatic stellate cells influence Th1/Th2 profile in vitro. World J Gastroenterol 2015; 21(23): 7165-7171
URL	http://www.wjgnet.com/1007-9327/full/v21/i23/7165.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i23.7165

Full Article (PDF)	WJG-21-7165.pdf
Full Article (Word)	WJG-21-7165.doc
Manuscript File	14908-Review.doc
Answering Reviewers	14908-Answering reviewers.pdf
Audio Core Tip	14908-Audio core tip.wav
Biostatistics Review Certificate	14908-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	14908-Conflict-of-interest statement.pdf
Copyright License Agreement	14908-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	14908-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	14908-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	14908-Language certificate.pdf
Peer-review Report	14908-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	14908-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	14908-Scientific misconduct check.pdf
Scientific Editor Work List	14908-Scientific editor work list.pdf