Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	14911
Country	Pakistan

Received	2014-10-30 08:26
Peer-Review Started	2014-11-02 14:16
To Make the First Decision	2014-12-12 17:26
Return for Revision	2014-12-16 14:23
Revised	2015-01-01 14:45
Second Decision	2015-01-14 09:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-01-20 16:43
Articles in Press	2015-01-20 16:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-14 19:53
Publish the Manuscript Online	2015-05-18 10:33

ISSN	1948-5190 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Is it time to replace propranolol with carvedilol for portal hypertension?
Manuscript Source	Invited Manuscript
All Author List	Shahab Abid, Saadat Ali, Muhammad Asif Baig and Anam Akbar Waheed
Funding Agency and Grant Number
Corresponding Author	Dr. Shahab Abid, Professor and Head, Section of Gastroenterology, Department of Medicine, Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan. shahab.abid@aku.edu
Key Words	Portal hypertension; Chronic liver disease; Non-selective beta-blockers; Propranolol; Carvedilol
Core Tip	Carvedilol is a promising agent among the beta blockers of recent time that has shown significant effects in portal hypertension hemodynamics. For primary prophylaxis of variceal bleeding, the effects of carvedilol were compared to band ligation in a few trials and showed some promise, but there has been no comparison with propranolol. Patients not responding to propranolol have shown clinical response to carvedilol, opening a new window of clinical application. For secondary prophylaxis of variceal bleeding, carvedilol has been shown to be effective. However no head-to-head trials comparing propranolol and carvedilol for variceal re-bleeding were found in literature.
Publish Date	2015-05-18 10:33
Citation	Abid S, Ali S, Baig MA, Waheed AA. Is it time to replace propranolol with carvedilol for portal hypertension? World J Gastrointest Endosc 2015; 7(5): 532-539
URL	http://www.wjgnet.com/1948-5190/full/v7/i5/532.htm
DOI	http://dx.doi.org/10.4253/wjge.v7.i5.532

Full Article (PDF)	WJGE-7-532.pdf
Full Article (Word)	WJGE-7-532.doc
Manuscript File	14911-Review.docx
Answering Reviewers	14911-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14911-Conflict-of-interest statement.pdf
Copyright License Agreement	14911-Copyright assignment.pdf
Peer-review Report	14911-Peer review(s).pdf
Scientific Misconduct Check	14911-CrossCheck.jpg
Scientific Editor Work List	14911-Scientific editor work list.pdf