Publication Name	World Journal of Diabetes
Manuscript ID	14938
Country	Pakistan

Received	2014-10-31 08:43
Peer-Review Started	2014-11-01 09:47
First Decision by Editorial Office Director
Return for Revision	2014-12-31 09:52
Revised	2015-01-19 00:00
Publication Fee Transferred
Second Decision by Editor	2015-02-03 19:43
Second Decision by Editor-in-Chief	2015-02-06 16:29
Final Decision by Editorial Office Director	2015-02-11 15:56
Articles in Press	2015-02-11 15:56
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-13 14:11
Publish the Manuscript Online	2015-05-15 19:54

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Genetics & Heredity
Manuscript Type	Minireviews
Article Title	Gene-gene, gene-environment, gene-nutrient interactions and single nucleotide polymorphisms of inflammatory cytokines
Manuscript Source	Invited Manuscript
All Author List	Amina Nadeem, Sadaf Mumtaz, Abdul Khaliq Naveed, Muhammad Aslam, Arif Siddiqui, Ghulam Mustafa Lodhi and Tausif Ahmad
Funding Agency and Grant Number
Corresponding Author	Dr. Amina Nadeem, Associate Professor, Department of Physiology, Army Medical College, National University of Sciences and Technology, NUST Campus, H-12, Islamabad 46000, Pakistan. aminanadeem@amcollege.nust.edu.pk
Key Words	Cytokines; Gene-environment interaction; Diabetes mellitus; Single nucleotide polymorphism; Gene-gene interaction
Core Tip	Single nucleotide polymorphisms (SNPs) in inflammatory cytokines play role in insulin resistance and type 2 diabetes mellitus (T2DM). These SNPs are found to be correlated with cytokine serum levels, body mass index, insulin resistance and dyslipidemia although these findings are challenged by other studies. Gene-gene, gene-environment and gene-nutrient interactions alter the impact of these SNPs in pathogenesis of T2DM. These interactions may explain the inter-ethnic variations in role of inflammatory cytokines in T2DM reported in international studies. This mini-review highlights these gene-genes, gene-environment and gene-nutrient interactions and their impact on inflammatory cytokine SNPs.
Publish Date	2015-05-15 19:54
Citation	Nadeem A, Mumtaz S, Naveed AK, Aslam M, Siddiqui A, Lodhi GM, Ahmad T. Gene-gene, gene-environment, gene-nutrient interactions and single nucleotide polymorphisms of inflammatory cytokines. World J Diabetes 2015; 6(4): 642-647
URL	http://www.wjgnet.com/1948-9358/full/v6/i4/642.htm
DOI	http://dx.doi.org/10.4239/wjd.v6.i4.642

Full Article (PDF)	WJD-6-642.pdf
Full Article (Word)	WJD-6-642.doc
Manuscript File	14938-Review.docx
Answering Reviewers	14938-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14938-Conflict-of-interest statement.pdf
Copyright License Agreement	14938-Copyright assignment.pdf
Peer-review Report	14938-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	14938-Journal Editor-in-Chief Review Report.pdf
Scientific Misconduct Check	14938-Scientific misconduct check.pdf
Scientific Editor Work List	14938-Scientific editor work list.pdf