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Articles Published Processes
5/13/2015 10:38:00 AM | Browse: 1057 | Download: 1943
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Received |
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2014-10-31 17:46 |
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Peer-Review Started |
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2014-11-03 08:21 |
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To Make the First Decision |
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2014-11-26 18:20 |
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Return for Revision |
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2014-12-04 17:47 |
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Revised |
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2014-12-22 11:12 |
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Second Decision |
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2015-02-02 10:35 |
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Accepted by Journal Editor-in-Chief |
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2015-02-04 01:48 |
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Accepted by Executive Editor-in-Chief |
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2015-02-11 15:19 |
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Articles in Press |
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2015-02-11 16:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-03-11 16:49 |
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Typeset the Manuscript |
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2015-04-21 09:42 |
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Publish the Manuscript Online |
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2015-05-13 10:38 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Autophagy in anti-apoptotic effect of augmenter of liver regeneration in HepG2 cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hong-Bo Shi, Hai-Qing Sun, Hong-Lin Shi, Feng Ren, Yu Chen, De-Xi Chen, Jin-Li Lou and Zhong-Ping Duan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81300349 |
| National Natural Science Foundation of China |
81270532 |
| Beijing Natural Science Foundation |
7144216 |
| Beijing Nova Program |
Z131107000413016 |
| Project of Science and Technology Activities of Preferred Overseas Personnel of Beijing (2014) |
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| Project of Cultivation of High Level Medical Technical Personnel in Health System of Beijing |
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| Corresponding Author |
Zhong-Ping Duan, MD, PhD, Professor of medicine, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China. duan2517@163.com |
| Key Words |
Autophagy; Augmenter of liver regeneration; Apoptosis; HepG2 cells |
| Core Tip |
Recent studies have found that augmenter of liver regeneration (ALR) plays an important role in suppressing hepatocyte apoptosis, although the mechanism remains unknown. Our study shows that ALR plays an important role in increasing the level of autophagy in HepG2 cells. The protective effect of ALR was significantly attenuated or abolished when autophagy was inhibited, indicating that the anti-apoptotic effect of ALR may be related to autophagy. Hence, we conclude that ALR protects cells against apoptosis partly by increasing autophagic activity in HepG2 cells and may be valuable for developing new therapeutic treatments for liver disease. |
| Publish Date |
2015-05-13 10:38 |
| Citation |
Shi HB, Sun HQ, Shi HL, Ren F, Chen Y, Chen DX, Lou JL, Duan ZP. Autophagy in anti-apoptotic effect of augmenter of liver regeneration in HepG2 cells. World J Gastroenterol 2015; 21(17): 5250-5258 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i17/5250.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i17.5250 |
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