Publication Name	World Journal of Gastroenterology
Manuscript ID	14963
Country	China

Received	2014-11-02 15:46
Peer-Review Started	2014-11-03 08:51
To Make the First Decision	2014-11-26 18:20
Return for Revision	2014-12-04 18:04
Revised	2014-12-18 20:51
Second Decision	2015-02-10 21:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-11 15:22
Articles in Press	2015-02-11 16:15
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-03-10 17:47
Typeset the Manuscript	2015-05-20 10:58
Publish the Manuscript Online	2015-06-11 10:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Transplantation
Manuscript Type	Basic Study
Article Title	Transplantation of insulin-producing cells to treat diabetic rats after 90% pancreatectomy
Manuscript Source	Unsolicited Manuscript
All Author List	Ya-Bin Yu, Jian-Min Bian and Dian-Hua Gu
Funding Agency and Grant Number
Corresponding Author	Dian-Hua Gu, MD, Department of Hepatobiliary Surgery, Huai’an First People’s Hospital, Nanjing Medical University, No. 140 Hanzhong Road, Huai’an 223300, Jiangsu Province, China. 531665908@qq.com
Key Words	Human umbilical cord mesenchymal stem cells; 90% pancreatectomy; Diabetic mellitus
Core Tip	It is well known that islet transplantation can decrease the morbidity related to diabetes mellitus (DM) after total pancreatectomy (TP); however, islet shortage limits its application. To solve the islet shortage problem, we tried to induce mesenchymal stem cells isolated from human Wharton’s jelly to differentiate into insulin-producing cells (IPCs) in this study. To imitate the pathophysiological status of diabetic patients after TP, we used Sprague-Dawley rats after 90% pancreatectomy as a model of type 1 DM. We for the first time tested the possible curative effects of transplanting IPCs differentiated from umbilical cord mesenchymal stem cells into the model rats.
Publish Date	2015-06-11 10:11
Citation	Yu YB, Bian JM, Gu DH. Transplantation of insulin-producing cells to treat diabetic rats after 90% pancreatectomy. World J Gastroenterol 2015; 21(21): 6582-6590
URL	http://www.wjgnet.com/1007-9327/full/v21/i21/6582.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i21.6582

Full Article (PDF)	WJG-21-6582.pdf
Full Article (Word)	WJG-21-6582.doc
Manuscript File	14963-Review.doc
Answering Reviewers	14963-Answering reviewers.pdf
Copyright License Agreement	14963-Copyright assignment.pdf
Peer-review Report	14963-Peer-review(s).pdf
Scientific Misconduct Check	14963-Scientific misconduct check.pdf
Scientific Editor Work List	14963-Scientific editor work list.pdf