Publication Name	World Journal of Nephrology
Manuscript ID	14965
Country	United States

Received	2014-11-02 12:27
Peer-Review Started	2014-11-09 14:06
To Make the First Decision	2014-11-27 12:07
Return for Revision	2014-12-07 18:26
Revised	2014-12-08 01:33
Second Decision	2015-05-08 17:48
Accepted by Journal Editor-in-Chief	2015-05-11 03:56
Accepted by Executive Editor-in-Chief	2015-05-18 17:08
Articles in Press	2015-05-18 17:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-30 15:43
Publish the Manuscript Online	2015-07-06 18:45

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	Epigenetics of epithelial Na+ channel-dependent sodium uptake and blood pressure regulation
Manuscript Source	Invited Manuscript
All Author List	Wenzheng Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health Grant 2R01 DK080236 06A1
Corresponding Author	Wenzheng Zhang, Associate Professor, Department of Internal Medicine, University of Texas Medical School at Houston, MSB 5.135, 6431 Fannin, Houston, TX 77030, United States. wenzheng.zhang@uth.tmc.edu
Key Words	Gene transcription; Chromatin; Epithelial sodium channel; Histone; Blood pressure
Core Tip	The epithelial Na+ channel (ENaC) is a key player in sodium transport and blood pressure control. This minireview summarizes the epigenetic mechanisms governing the transcription of ?ENaC. The epigenetic control involves Dot1a-Af9-mediated repression through targeted hypermethylation of histone H3 K79. Aldosterone relieves the repression by decreasing Dot1a and Af9 mRNA levels and by weakening the protein-protein interaction between Dot1a and Af9 interaction via Sgk1-catalyzed Af9 phosphorylation. Aldosterone-independent mechanism involves Af17 as a competitor of Af9 for binding Dot1a and stimulator of Dot1a nuclear export. Af17-/- mice exhibit decreased Na+ reabsorption and lowered blood pressure, indicating the significance of this epigenetic control.
Publish Date	2015-07-06 18:45
Citation	Zhang W. Epigenetics of epithelial Na+ channel-dependent sodium uptake and blood pressure regulation. World J Nephrol 2015; 4(3): 363-366
URL	http://www.wjgnet.com/2220-6124/full/v4/i3/363.htm
DOI	http://dx.doi.org/10.5527/wjn.v4.i3.363

Full Article (PDF)	WJN-4-363.pdf
Full Article (Word)	WJN-4-363.doc
Manuscript File	14965-Review.doc
Answering Reviewers	14965-Answering reviewers.pdf
Audio Core Tip	14965-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	14965-Conflict-of-interest statement.pdf
Copyright License Agreement	14965-Copyright assignment.pdf
Peer-review Report	14965-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	14965-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	14965-Scientific misconduct check.pdf
Scientific Editor Work List	14965-Scientific editor work list.pdf