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Articles Published Processes
9/15/2014 8:55:00 PM | Browse: 1027 | Download: 1355
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Received |
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2012-12-16 09:52 |
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Peer-Review Started |
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2012-12-17 17:31 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2013-01-23 20:30 |
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Revised |
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2013-02-01 23:53 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2013-03-22 11:59 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2013-03-23 09:19 |
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Articles in Press |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2013-06-06 07:56 |
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Publish the Manuscript Online |
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2013-06-28 23:55 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Interaction of 14-3-3σ with KCMF1 suppresses the proliferation and colony formation of human colon cancer stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jian Zou, Lin Mi, Xiao-Feng Yu and Jie Dong |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Medical Guidance Projects of Shanghai Science Committee |
10411961800 |
| National Natural Science Foundation of China |
81101617 |
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| Corresponding Author |
Xiao-Feng Yu, Professor, Department of Gastroenterology, Huadong Hospital, Fudan University, 221 Yan an Xi Road, Shanghai 200040, China. zoujian-dj@163.com |
| Key Words |
14-3-3σ protein; Interacting proteins; Yeast two-hybrid system; Colon cancer stem cells |
| Core Tip |
Of the 14-3-3 proteins, tumor-suppressor activity has most clearly been defined for 14-3-3σ. In the study, we constructed 14-3-3σ bait gene and expressed as a fusion to the GAL4 DNA-binding domain successfully. Using the yeast two-hybrid system, we found novel binding proteins from the HeLa cDNA library which closely interact with 14-3-3σ. Our results also suggest that 14-3-3σ may interact with potassium channel modulatory factor 1 (KCMF1) protein. The knock-down expression of 14-3-3σ and KCMF1 proteins significantly inhibited proliferation and colony formation of SW1116csc cells. So, 14-3-3σ and other proteins may be involved in proliferation and colony formation of human colon cancer stem cells. |
| Publish Date |
2013-06-28 23:55 |
| Citation |
Zou J, Mi L, Yu XF, Dong J. Interaction of 14-3-3σ with KCMF1 suppresses the proliferation and colony formation of human colon cancer stem cells. World J Gastroenterol 2013; 19(24): 3770-3780 |
| URL |
http://www.wjgnet.com/1007-9327/full/v19/i24/3770.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v19.i24.3770 |
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