| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Inhibitory effects of emodin, baicalin, schizandrin and berberine on hefA gene: Treatment of Helicobacter pylori-induced multidrug resistance
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Qiang Huang, Gan-Rong Huang, Ming-Hui Wu, Hua-Ying Tang, Zan-Song Huang, Xi-Han Zhou, Wen-Qiang Yu, Jian-Wei Su, Xiao-Qiang Mo, Bing-Pu Chen, Li-Juan Zhao, Xiao-Feng Huang, Hong-Yu Wei and Lian-Deng Wei |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangxi Key Discipline Fund (Pathogenic Microbiology) |
[2013]16 |
| Key Laboratory Fund of Colleges and Universities in Guangxi |
Gui Jiao Ke Yan [2014]6 |
| National Natural Science Foundation of China |
31460023 |
| Natural Science Foundation of Guangxi |
2014GXNSFAA118206 |
|
| Corresponding Author |
Yan-Qiang Huang, Associate Professor, Department of Medical Microbiology and Immunology, Youjiang Medical College for Nationalities, No. 98 Countryside Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. hyq77615@163.com |
| Key Words |
Traditional Chinese medicine; Multidrug resistance; Helicobacter pylori; Efflux pump; hefA |
| Core Tip |
Clinical signs of Helicobacter pylori (H. pylori)-induced drug resistance have become more and more prevalent, thus resulting in reduced cure rates. In this study, we used herbal extracts, such as berberine, to inhibit multidrug resistance in H. pylori. The results indicated that the minimum inhibitory concentration of amoxicillin and tetracycline was lowered after the intervention; the regulatory mechanism was related to down-regulation of efflux pump hefA mRNA expression. This suggests a novel strategy for prophylaxis and treatment of H. pylori-induced resistance. |
| Publish Date |
2015-04-15 11:01 |
| Citation |
Huang YQ, Huang GR, Wu MH, Tang HY, Huang ZS, Zhou XH, Yu WQ, Su JW, Mo XQ, Chen BP, Zhao LJ, Huang XF, Wei HY, Wei LD. Inhibitory effects of emodin, baicalin, schizandrin and berberine on hefA gene: Treatment of Helicobacter pylori induced-multidrug resistance. World J Gastroenterol 2015; 21(14): 4225-4231 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i14/4225.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i14.4225 |
