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Articles Published Processes
6/11/2015 10:11:00 AM | Browse: 1223 | Download: 1786
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Received |
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2014-11-03 08:30 |
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Peer-Review Started |
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2014-11-03 09:39 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2015-01-05 11:32 |
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Revised |
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2015-02-03 19:26 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2015-02-10 21:20 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2015-02-11 15:27 |
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Articles in Press |
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2015-02-11 16:16 |
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Edit the Manuscript by Language Editor |
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2015-03-05 04:53 |
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Typeset the Manuscript |
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2015-05-20 18:31 |
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Publish the Manuscript Online |
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2015-06-11 10:11 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Precore/basal core promoter mutants quantification throughout phases of hepatitis B virus infection by Simpleprobe
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Hui Tu, Ying Lv, Yong-Mei Zhang, Wei Hou, Jin-Yu Wang, Yi-Jun Zhang, Hong-Yan Liu, Hao-Xiang Zhu, Yan-Li Qin, Ri-Cheng Mao and Ji-Ming Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science and Technology Major Project of China |
2012ZX10002007-001-002 |
| National Science and Technology Major Project of China |
2013ZX10002001 (to Zhang JM) |
| National Natural Science Foundation of China |
81271833 |
| National Natural Science Foundation of China |
81471933 (to Zhang JM) |
| Science and Technology Plan Project of Taizhou, Zhejiang province |
1402ky19 (to Tu WH and Hou W) |
| Scientific Research Project of Taizhou University, Zhejiang province |
2014PY054 (to Tu WH and Hou W) |
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| Corresponding Author |
Ji-Ming Zhang, MD, Department of Infectious Disease, Huashan Hospital, Fudan University, No. 12 Wulumuqi Zhong Road, Shanghai 200040, China. jmzhang@fudan.edu.cn |
| Key Words |
Precore mutant; Basal core promoter mutant; Hepatitis B virus; Quantification; Hepatitis B early antigen titers |
| Core Tip |
During the natural history of hepatitis B virus infection, no evidence for the correlation between the dynamic alteration of precore/basal core promoter (PC/BCP) mutated strains and hepatitis B early antigen titers has been obtained by qualitative analysis. Using Simpleprobe ultrasensitive quantification of the wild-type and mutated hepatitis B virus (HBV) strains, we provided new insights into the process by which PC/BCP-mutated strains become dominant during the natural course of infection. Thus, we provide important clues for the evaluation of HBV infection status and the corresponding host immune responses. |
| Publish Date |
2015-06-11 10:11 |
| Citation |
Tu WH, Lv Y, Zhang YM, Hou W, Wang JY, Zhang YJ, Liu HY, Zhu HX, Qin YL, Mao RC, Zhang JM. Precore/basal core promoter mutants quantification throughout phases of hepatitis B virus infection by Simpleprobe. World J Gastroenterol 2015; 21(21): 6639-6648 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i21/6639.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i21.6639 |
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