Publication Name	World Journal of Gastroenterology
Manuscript ID	14987
Country	China

Received	2014-11-03 08:30
Peer-Review Started	2014-11-03 09:39
To Make the First Decision	2014-12-26 13:32
Return for Revision	2015-01-05 11:32
Revised	2015-02-03 19:26
Second Decision	2015-02-10 21:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-11 15:27
Articles in Press	2015-02-11 16:16
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-03-05 04:53
Typeset the Manuscript	2015-05-20 18:31
Publish the Manuscript Online	2015-06-11 10:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Precore/basal core promoter mutants quantification throughout phases of hepatitis B virus infection by Simpleprobe
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Hui Tu, Ying Lv, Yong-Mei Zhang, Wei Hou, Jin-Yu Wang, Yi-Jun Zhang, Hong-Yan Liu, Hao-Xiang Zhu, Yan-Li Qin, Ri-Cheng Mao and Ji-Ming Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Science and Technology Major Project of China 2012ZX10002007-001-002 National Science and Technology Major Project of China 2013ZX10002001 (to Zhang JM) National Natural Science Foundation of China 81271833 National Natural Science Foundation of China 81471933 (to Zhang JM) Science and Technology Plan Project of Taizhou, Zhejiang province 1402ky19 (to Tu WH and Hou W) Scientific Research Project of Taizhou University, Zhejiang province 2014PY054 (to Tu WH and Hou W)
Corresponding Author	Ji-Ming Zhang, MD, Department of Infectious Disease, Huashan Hospital, Fudan University, No. 12 Wulumuqi Zhong Road, Shanghai 200040, China. jmzhang@fudan.edu.cn
Key Words	Precore mutant; Basal core promoter mutant; Hepatitis B virus; Quantification; Hepatitis B early antigen titers
Core Tip	During the natural history of hepatitis B virus infection, no evidence for the correlation between the dynamic alteration of precore/basal core promoter (PC/BCP) mutated strains and hepatitis B early antigen titers has been obtained by qualitative analysis. Using Simpleprobe ultrasensitive quantification of the wild-type and mutated hepatitis B virus (HBV) strains, we provided new insights into the process by which PC/BCP-mutated strains become dominant during the natural course of infection. Thus, we provide important clues for the evaluation of HBV infection status and the corresponding host immune responses.
Publish Date	2015-06-11 10:11
Citation	Tu WH, Lv Y, Zhang YM, Hou W, Wang JY, Zhang YJ, Liu HY, Zhu HX, Qin YL, Mao RC, Zhang JM. Precore/basal core promoter mutants quantification throughout phases of hepatitis B virus infection by Simpleprobe. World J Gastroenterol 2015; 21(21): 6639-6648
URL	http://www.wjgnet.com/1007-9327/full/v21/i21/6639.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i21.6639

Full Article (PDF)	WJG-21-6639.pdf
Full Article (Word)	WJG-21-6639.doc
Manuscript File	14987-Review.docx
Answering Reviewers	14987-Answering reviewers.pdf
Copyright License Agreement	14987-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	14987-Language certificate.pdf
Peer-review Report	14987-Peer-review(s).pdf
Scientific Misconduct Check	14987-Scientific misconduct check.pdf
Scientific Editor Work List	14987-Scientific editor work list.pdf