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Articles Published Processes
5/18/2015 5:02:00 PM | Browse: 1094 | Download: 1966
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Received |
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2014-11-10 09:46 |
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Peer-Review Started |
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2014-11-10 21:46 |
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To Make the First Decision |
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2014-12-11 20:23 |
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Return for Revision |
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2014-12-16 08:56 |
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Revised |
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2014-12-29 18:12 |
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Second Decision |
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2015-02-02 10:28 |
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Accepted by Journal Editor-in-Chief |
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2015-02-04 01:59 |
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Accepted by Executive Editor-in-Chief |
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2015-03-12 16:19 |
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Articles in Press |
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2015-03-12 16:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-03-31 16:26 |
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Typeset the Manuscript |
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2015-04-24 13:51 |
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Publish the Manuscript Online |
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2015-05-18 17:02 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Phycocyanobilin accelerates liver regeneration and reduces mortality rate in carbon tetrachloride-induced liver injury mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jie Liu, Qing-Yu Zhang, Li-Ming Yu, Bin Liu, Ming-Yi Li and Run-Zhi Zhu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhanjiang Key Laboratory of Hepatobiliary Diseases |
2013A402-4 |
| Medical Research Funding of Affiliated Hospital of Guangdong Medical College |
QK1319 |
| Medical Research Funding of Guangdong Province, China |
B2014306 |
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| Corresponding Author |
Run-Zhi Zhu, PhD, Department of Hepato¬biliary Surgery, Affiliated Hospital of Guangdong Medical College, South NO. 57 Renmin Dadao, Zhanjiang 524001, Guangdong Province, China. hepatolab@163.com |
| Key Words |
Liver injury; Hepatoprotective; Tumor necrosis factor-alpha; Phycocyanobilin; Cytochrome C |
| Core Tip |
Our research confirmed that phycocyanobilin (PCB) plays a hepatoprotective role on carbon tetrachloride-induced acute liver injury mice. It was shown that PCB has a strongly anti-inflammatory effect when the liver suffered oxidative damage. The results showed that PCB could accelerate liver regeneration, reduce apoptosis and necrosis of the hepatocytes by regulating the expression of hepatocyte growth factor, transforming growth factor (TGF)-?, TGF-?, tumor necrosis factor-? and interleukin-6. In addition, PCB could significantly improve the survival probability of the acute liver injury mice. |
| Publish Date |
2015-05-18 17:02 |
| Citation |
Liu J, Zhang QY, Yu LM, Liu B, Li MY, Zhu RZ. Phycocyanobilin accelerates liver regeneration and reduces mortality rate in carbon tetrachloride-induced liver injury mice. World J Gastroenterol 2015; 21(18): 5465-5472 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i18/5465.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i18.5465 |
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