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5/18/2015 5:02:00 PM | Browse: 349 | Download: 485
Publication Name World Journal of Gastroenterology
Manuscript ID 15088
Country of Manuscript Source China
Received
2014-11-10 09:46
Peer-Review Started
2014-11-10 21:46
To Make the First Decision
2014-12-11 20:23
Return for Revision
2014-12-16 08:56
Revised
2014-12-29 18:12
Second Decision
2015-02-02 10:28
Accepted by Journal Editor-in-Chief
2015-02-04 01:59
Accepted by Company Editor-in-Chief
2015-03-12 16:19
Articles in Press
2015-03-12 16:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-03-31 16:26
Typeset the Manuscript
2015-04-24 13:51
Publish the Manuscript Online
2015-05-18 17:02
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Phycocyanobilin accelerates liver regeneration and reduces mortality rate in carbon tetrachloride-induced liver injury mice
Manuscript Source Unsolicited Manuscript
All Author List Jie Liu, Qing-Yu Zhang, Li-Ming Yu, Bin Liu, Ming-Yi Li and Run-Zhi Zhu
Funding Agency and Grant Number
Funding Agency Grant Number
Zhanjiang Key Laboratory of Hepatobiliary Diseases 2013A402-4
Medical Research Funding of Affiliated Hospital of Guangdong Medical College QK1319
Medical Research Funding of Guangdong Province, China B2014306
Corresponding author Run-Zhi Zhu, PhD, Department of Hepato¬biliary Surgery, Affiliated Hospital of Guangdong Medical College, South NO. 57 Renmin Dadao, Zhanjiang 524001, Guangdong Province, China. hepatolab@163.com
Keywords Liver injury; Hepatoprotective; Tumor necrosis factor-alpha; Phycocyanobilin; Cytochrome C
Core Tip Our research confirmed that phycocyanobilin (PCB) plays a hepatoprotective role on carbon tetrachloride-induced acute liver injury mice. It was shown that PCB has a strongly anti-inflammatory effect when the liver suffered oxidative damage. The results showed that PCB could accelerate liver regeneration, reduce apoptosis and necrosis of the hepatocytes by regulating the expression of hepatocyte growth factor, transforming growth factor (TGF)-?, TGF-?, tumor necrosis factor-? and interleukin-6. In addition, PCB could significantly improve the survival probability of the acute liver injury mice.
Publish Date 2015-05-18 17:02
Citation Liu J, Zhang QY, Yu LM, Liu B, Li MY, Zhu RZ. Phycocyanobilin accelerates liver regeneration and reduces mortality rate in carbon tetrachloride-induced liver injury mice. World J Gastroenterol 2015; 21(18): 5465-5472
Url http://www.wjgnet.com/1007-9327/full/v21/i18/5465.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i18.5465
Full Article (PDF) WJG-21-5465.pdf
Full Article (Word) WJG-21-5465.doc
Manuscript File 15088-Review.doc
Answering Reviewers 15088-Answering reviewers.pdf
Biostatistics Review Certificate 15088-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 15088-Conflict-of-interest statement.pdf
Copyright License Agreement 15088-Copyright assignment.pdf
Data Sharing Statement 15088-Data sharing statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 15088-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 15088-Institutional review board statement.pdf
Peer-review Report 15088-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 15088-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 15088-Scientific misconduct check.pdf
Scientific Editor Work List 15088-Scientific editor work list.pdf