Publication Name	World Journal of Gastroenterology
Manuscript ID	15094
Country	China

Received	2014-11-08 12:09
Peer-Review Started	2014-11-08 21:11
To Make the First Decision	2014-12-11 20:23
Return for Revision	2014-12-16 08:57
Revised	2014-12-31 09:52
Second Decision	2015-02-02 10:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-13 10:13
Articles in Press	2015-02-13 11:28
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-03-31 09:44
Typeset the Manuscript	2015-04-28 12:12
Publish the Manuscript Online	2015-05-18 17:02

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Dihydromyricetin alleviates carbon tetrachloride-induced acute liver injury via JNK-dependent mechanism in mice
Manuscript Source	Unsolicited Manuscript
All Author List	Jun Xie, Jie Liu, Tu-Ming Chen, Qing Lan, Qing-Yu Zhang, Bin Liu, Dong Dai, Wei-Dong Zhang, Li-Ping Hu and Run-Zhi Zhu
Funding Agency and Grant Number	Funding Agency Grant Number Initial Fund of Guangdong Medical College XB1338 Medical Research Fund of Guangdong Province B2014306 Research Fund of Guangdong Medical College M2013024
Corresponding Author	Run-Zhi Zhu, PhD, Clinical Research Center, Xuyi People’s Hospital, No. 3 East Huaihe Road, Xucheng Town, Xuyi 211700, Jiangsu Province, China. hepatolab@163.com
Key Words	Dihydromyricetin; Liver regeneration; Tumor necrosis factor-α
Core Tip	Our research confirmed that dihydromyricetin (DHM) plays an anti-inflammatory role in the carbon tetrachloride (CCl4) induced acute liver injury mice. It was shown that DHM could alleviate CCl4-induced acute liver injury by reducing apoptosis and accelerating proliferation of hepatocytes. Furthermore, DHM treatment up-regulated Jun kinase expression in liver tissue, and the mice which were injected with SP600125 could not survive in the acute liver failure induced by lethal dose CCl4 injection.
Publish Date	2015-05-18 17:02
Citation	Xie J, Liu J, Chen TM, Lan Q, Zhang QY, Liu B, Dai D, Zhang WD, Hu LP, Zhu RZ. Dihydromyricetin alleviates carbon tetrachloride-induced acute liver injury via JNK-dependent mechanism in mice. World J Gastroenterol 2015; 21(18): 5473-5481
URL	http://www.wjgnet.com/1007-9327/full/v21/i18/5473.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i18.5473

Full Article (PDF)	WJG-21-5473.pdf
Full Article (Word)	WJG-21-5473.doc
Manuscript File	15094-Review.doc
Answering Reviewers	15094-Answering reviewers.pdf
Biostatistics Review Certificate	15094-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	15094-Conflict-of-interest statement.pdf
Copyright License Agreement	15094-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	15094-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	15094-Institutional review board statement.pdf
Peer-review Report	15094-Peer-review(s).pdf
Scientific Misconduct Check	15094-Scientific misconduct check.pdf
Scientific Editor Work List	15094-Scientific editor work list.pdf