Publication Name	World Journal of Transplantation
Manuscript ID	1511
Country	Italy

Received	2012-12-17 10:49
Peer-Review Started	2012-12-17 18:43
To Make the First Decision	2013-03-11 15:15
Return for Revision	2013-03-19 14:53
Revised	2013-04-07 22:05
Second Decision	2013-05-09 14:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-05-10 06:42
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-28 16:15
Publish the Manuscript Online	2013-06-07 14:05

ISSN	2220-3230 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Transplantation
Manuscript Type	Frontier
Article Title	Is it time to give up with calcineurin inhibitors in kidney transplantation?
Manuscript Source	Invited Manuscript
All Author List	Maurizio Salvadori and Elisabetta Bertoni
Funding Agency and Grant Number
Corresponding Author	Maurizio Salvadori, MD, Professor, Department of Renal Transplantation, Careggi University Hospital, viale Pieraccini 15, 50139 Florence, Italy. maurizio.salvadori1@gmail.com
Key Words	Calcineurin inhibitors nephrotoxicity; Calcineurin inhibitors withdrawal; Calcineurin inhibitors minimization; Calcineurin inhibitors avoidance; Donor specific antibodies; Antibody mediated rejection; New drugs in renal transplantation
Core Tip	Calcineurin inhibitors (CNIs) based therapy is still a cornerstone in renal transplantation. Nevertheless, with the use of such drugs the long-term graft survival did not improve. Causes may be nephrotoxicity, underimmunesuppression or both. All the trials attempting to CNIs sparing have been examined, but nephrotoxicity doesn’t seem to be responsible for the lack of long-term improvement. In recent years emerged the problem of anti-human leukocyte antigen antibodies not adequately suppressed by the CNIs based therapy. New drugs are necessary, but the pipeline seems to be almost empty now. To date the only promising drug strategy is the co-stimulation blockade, whose four-year results are reported.
Publish Date	2013-06-07 14:05
Citation	Salvadori M, Bertoni E. Is it time to give up with calcineurin inhibitors in kidney transplantation? World J Transplant 2013; 3(2): 7-25
URL	http://www.wjgnet.com/2220-3230/full/v3/i2/7.htm
DOI	http://dx.doi.org/10.5500/wjt.v3.i2.7

Full Article (PDF)	WJT-3-7.pdf
Manuscript File	1511-Review.docx
Answering Reviewers	1511-Answering reviewers.doc
Copyright License Agreement	1511-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	1511-Language certificate.pdf
Peer-review Report	1511-Peer review(s).pdf
Scientific Editor Work List	1511-Scientific editor work list.doc